Mertins, Philipp

Proteogenomics connects somatic mutations to signalling in breast cancer

CPTAC, N., Mertins, P., Mani, D. R., Ruggles, K. V., Gillette, M. A., Clauser, K. R., Wang, P., Wang, X., Qiao, J. W., Cao, S., et al. (2016) · Nature

Advanced Proteomics Techniques and ApplicationsCancer Genomics and Diagnostics

Cited by 1,676

Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

Zhang, H., Liu, T., Zhang, Z., Payne, S. H., Zhang, B., McDermott, J. E., Zhou, J.-Y., Petyuk, V. A., Chen, L., Ray, D., et al. (2016) · Cell

Ovarian cancer diagnosis and treatmentAdvanced Proteomics Techniques and Applications

Cited by 1,029

Transcriptional and Translational Differences of Microglia from Male and Female Brains

Guneykaya, D., Ivanov, A., Hernandez, D. P., Haage, V., Wojtas, B., Meyer, N., Maricos, M., Jordan, P., Buonfiglioli, A., Gielniewski, B., et al. (2018) · Cell Reports

Neuroinflammation and Neurodegeneration MechanismsSex and Gender in Healthcare

Cited by 477

Dynamic profiling of the protein life cycle in response to pathogens

Jovanovic, M., Rooney, M. S., Mertins, P., Przybylski, D., Chevrier, N., Satija, R., Rodriguez, E. H., Fields, A. P., Schwartz, S., Raychowdhury, R., et al. (2015) · Science

Advanced Proteomics Techniques and ApplicationsGene Regulatory Network Analysis

Cited by 460

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

Parnas, O., Jovanovic, M., Eisenhaure, T. M., Herbst, R. H., Dixit, A., Ye, C. J., Przybylski, D., Platt, R. J., Tirosh, I., Sanjana, N. E., et al. (2015) · Cell

Immune Response and InflammationCRISPR and Genetic Engineering

Cited by 440

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

Wong, G. S., Zhou, J., Liu, J. B., Wu, Z., Xu, X., Li, T., Xu, D., Schumacher, S. E., Puschhof, J., McFarland, J., et al. (2018) · Nature Medicine

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 266

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

Müller, P. M., Rademacher, J., Bagshaw, R. D., Wortmann, C., Barth, C., van Unen, J., Alp, K. M., Giudice, G., Eccles, R. L., Heinrich, L. E., et al. (2020) · Nature Cell Biology

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 253

PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

Kahn, J. D., Miller, P. G., Silver, A. J., Sellar, R. S., Bhatt, S., Gibson, C., McConkey, M., Adams, D., Mar, B., Mertins, P., et al. (2018) · Blood

Protein Tyrosine PhosphatasesAcute Myeloid Leukemia Research

Cited by 225

Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits

Chevrier, N., Mertins, P., Artyomov, M. N., Shalek, A. K., Iannacone, M., Ciaccio, M. F., Gat-Viks, I., Tonti, E., DeGrace, M. M., Clauser, K. R., et al. (2011) · Cell

Immune Response and Inflammationinterferon and immune responses

Cited by 179

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome

Boehm, V., Wallmeroth, D., Wulf, P. O., Popp, O., Teixeira Alves, L. G., Reinecke, L., Riedel, M., Wyler, E., Franitza, M., Becker, K., et al. (2025) · Molecular Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 23

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated transcriptome in human cells

Boehm, V., Wallmeroth, D., Wulf, P. O., Alves, L. G. T., Popp, O., Riedel, M., Wyler, E., Franitza, M., Gerbracht, J. V., Becker, K., et al. (2024) · Molecular Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 23

Combining data independent acquisition with spike-in SILAC (DIA-SiS) improves proteome coverage and quantification

Welter, A. S., Gerwien, M., Kerridge, R., Alp, K. M., Mertins, P., & Selbach, M. (2024) · Molecular & Cellular Proteomics

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 18