Klopstock, Thomas

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

Bender, A., Krishnan, K. J., Morris, C. M., Taylor, G. A., Reeve, A. K., Perry, R. H., Jaros, E., Hersheson, J. S., Betts, J., Klopstock, T., et al. (2006) · Nature Genetics

Mitochondrial Function and PathologyParkinson's Disease Mechanisms and Treatments

Cited by 1,570

Genome-wide, large-scale production of mutant mice by ENU mutagenesis

de Angelis, M. H., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., et al. (2000) · Nature Genetics

Plant Genetic and Mutation StudiesCarcinogens and Genotoxicity Assessment

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A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

Enard, W., Gehre, S., Hammerschmidt, K., Hölter, S. M., Blass, T., Somel, M., Brückner, M. K., Schreiweis, C., Winter, C., Sohr, R., et al. (2009) · Cell

Genetics and Neurodevelopmental DisordersAnimal Vocal Communication and Behavior

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A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy.

Klopstock, T., Yu-Wai-Man, P., Dimitriadis, K., Rouleau, J., Heck, S., Bailie, M., Atawan, A., Chattopadhyay, S., Schubert, M., Garip, A., et al. (2011) · Brain

Neuroprotection in Cerebral IschemiaMitochondrial Function and Pathology

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Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

Kleinschnitz, C., Grund, H., Wingler, K., Armitage, M. E., Jones, E., Mittal, M., Barit, D., Schwarz, T., Geis, C., Kraft, P., et al. (2010) · PLoS Biology

Acute Ischemic Stroke ManagementNitric Oxide and Endothelin Effects

Cited by 447

Rapamycin extends murine lifespan but has limited effects on aging

Neff, F., Flores-Dominguez, D., Ryan, D. P., Horsch, M., Schröder, S., Adler, T., Afonso, L. C., Aguilar-Pimentel, J. A., Becker, L., Garrett, L., et al. (2013) · Journal of Clinical Investigation

Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

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Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients

Schüle, R., Wiethoff, S., Martus, P., Karle, K. N., Otto, S., Klebe, S., Klimpe, S., Gallenmüller, C., Kurzwelly, D., Henkel, D., et al. (2016) · Annals of Neurology

Hereditary Neurological DisordersGenetic Neurodegenerative Diseases

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Prevalence of sexual dimorphism in mammalian phenotypic traits

Karp, N. A., Mason, J., Beaudet, A. L., Benjamini, Y., Bower, L., Braun, R. E., Brown, S. D. M., Chesler, E. J., Dickinson, M. E., Flenniken, A. M., et al. (2017) · Nature Communications

Sex and Gender in HealthcareGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

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Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease

Kornblum, C., Nicholls, T. J., Haack, T. B., Schöler, S., Peeva, V., Danhauser, K., Hallmann, K., Zsurka, G., Rorbach, J., Iuso, A., et al. (2013) · Nature Genetics

Mitochondrial Function and PathologyDNA Repair Mechanisms

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Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy

Yu-Wai-Man, P., Newman, N. J., Carelli, V., Moster, M. L., Biousse, V., Sadun, A. A., Klopstock, T., Vignal-Clermont, C., Sergott, R. C., Rudolph, G., et al. (2020) · Science Translational Medicine

Retinal Development and DisordersVirus-based gene therapy research

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International consensus statement on the clinical and therapeutic management of Leber hereditary optic neuropathy

Carelli, V., Carbonelli, M., de Coo, I. F., Kawasaki, A., Klopstock, T., Lagrèze, W. A., La Morgia, C., Newman, N. J., Orssaud, C., Pott, J. W. R., et al. (2017) · Journal of Neuro-Ophthalmology

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

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Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset

Newman, N. J., Yu-Wai-Man, P., Carelli, V., Moster, M. L., Biousse, V., Vignal-Clermont, C., Sergott, R. C., Klopstock, T., Sadun, A. A., Barboni, P., et al. (2021) · Ophthalmology

Retinal Development and DisordersVirus-based gene therapy research

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Creatine for neuroprotection in neurodegenerative disease: end of story?

Bender, A., & Klopstock, T. (2016) · Amino Acids

Parkinson's Disease Mechanisms and TreatmentsNeuroprotection in Cerebral Ischemia

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Long-term creatine supplementation is safe in aged patients with Parkinson disease

Bender, A., Samtleben, W., Elstner, M., & Klopstock, T. (2008) · Nutrition Research

Muscle metabolism and nutritionParkinson's Disease Mechanisms and Treatments

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Intravitreal Gene Therapy vs. Natural History in Patients With Leber Hereditary Optic Neuropathy Carrying the m.11778G>A ND4 Mutation: Systematic Review and Indirect Comparison

Newman, N. J., Yu-Wai-Man, P., Carelli, V., Biousse, V., Moster, M. L., Vignal-Clermont, C., Sergott, R. C., Klopstock, T., Sadun, A. A., Girmens, J.-F., et al. (2021) · Frontiers in Neurology

Virus-based gene therapy researchGlaucoma and retinal disorders

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The phenotype associated with variants in TANGO2 may be explained by a dual role of the protein in ER‐to‐Golgi transport and at the mitochondria

Milev, M. P., Saint‐Dic, D., Zardoui, K., Klopstock, T., Law, C., Distelmaier, F., & Sacher, M. (2021) · Journal of Inherited Metabolic Disease

Cellular transport and secretionMetabolism and Genetic Disorders

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Safety of lenadogene nolparvovec gene therapy over 5 Years in 189 patients with leber hereditary optic neuropathy

VIGNAL-CLERMONT, C., YU-WAI-MAN, P., NEWMAN, N. J., CARELLI, V., MOSTER, M. L., BIOUSSE, V., SUBRAMANIAN, P. S., WANG, A.-G., DONAHUE, S. P., LEROY, B. P., et al. (2023) · American Journal of Ophthalmology

Virus-based gene therapy researchRetinal Development and Disorders

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Cross-sectional analysis of baseline visual parameters in subjects recruited into the RESCUE and REVERSE ND4-LHON gene therapy studies

Moster, M. L., Sergott, R. C., Newman, N. J., Yu-Wai-Man, P., Carelli, V., Bryan, M. S., Smits, G., Biousse, V., Vignal-Clermont, C., Klopstock, T., et al. (2021) · Journal of Neuro-Ophthalmology

Glaucoma and retinal disordersRetinal Development and Disorders

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