Horton, Jay D.

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 4,092

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

Ference, B. A., Ginsberg, H. N., Graham, I., Ray, K. K., Packard, C. J., Bruckert, E., Hegele, R. A., Krauss, R. M., Raal, F. J., Schunkert, H., et al. (2017) · European Heart Journal

Lipoproteins and Cardiovascular HealthAtherosclerosis and Cardiovascular Diseases

Cited by 3,962

Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity

Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology

Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 3,664

Human Fatty Liver Disease: Old Questions and New Insights

Cohen, J. C., Horton, J. D., & Hobbs, H. H. (2011) · Science

Liver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects

Cited by 2,089

Molecular mediators of hepatic steatosis and liver injury

Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 1,772

Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., et al. (2020) · European Heart Journal

Lipoproteins and Cardiovascular HealthAtherosclerosis and Cardiovascular Diseases

Cited by 1,601

Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation

Zhang, D.-W., Lagace, T. A., Garuti, R., Zhao, Z., McDonald, M., Horton, J. D., Cohen, J. C., & Hobbs, H. H. (2007) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 788

A highly durable RNAi therapeutic inhibitor of PCSK9

Fitzgerald, K., White, S., Borodovsky, A., Bettencourt, B. R., Strahs, A., Clausen, V., Wijngaard, P., Horton, J. D., Taubel, J., Brooks, A., et al. (2017) · New England Journal of Medicine

Lipoproteins and Cardiovascular HealthRNA Interference and Gene Delivery

Cited by 768

Nonalcoholic fatty liver disease and cardiovascular risk: a scientific statement from the American Heart Association

Duell, P. B., Welty, F. K., Miller, M., Chait, A., Hammond, G., Ahmad, Z., Cohen, D. E., Horton, J. D., Pressman, G. S., Toth, P. P., et al. (2022) · Arteriosclerosis, Thrombosis, and Vascular Biology

Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 727

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice

Lagace, T. A., Curtis, D. E., Garuti, R., McNutt, M. C., Park, S. W., Prather, H. B., Anderson, N. N., Ho, Y. K., Hammer, R. E., & Horton, J. D. (2006) · Journal of Clinical Investigation

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 681

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A. K., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., et al. (2014) · Cell

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 681

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

Rashid, S., Curtis, D. E., Garuti, R., Anderson, N. N., Bashmakov, Y., Ho, Y. K., Hammer, R. E., Moon, Y.-A., & Horton, J. D. (2005) · Proceedings of the National Academy of Sciences

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 679

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 669

Molecular biology of PCSK9: its role in LDL metabolism

HORTON, J., COHEN, J., & HOBBS, H. (2007) · Trends in Biochemical Sciences

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 621

Acetyl CoA carboxylase inhibition reduces hepatic steatosis but elevates plasma triglycerides in mice and humans: a bedside to bench investigation

Kim, C.-W., Addy, C., Kusunoki, J., Anderson, N. N., Deja, S., Fu, X., Burgess, S. C., Li, C., Ruddy, M., Chakravarthy, M., et al. (2017) · Cell Metabolism

Liver Disease Diagnosis and TreatmentCancer, Lipids, and Metabolism

Cited by 419

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

Moon, Y.-A., Liang, G., Xie, X., Frank-Kamenetsky, M., Fitzgerald, K., Koteliansky, V., Brown, M. S., Goldstein, J. L., & Horton, J. D. (2012) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 320

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors

Willnow, T. E., Rohlmann, A., Horton, J., Otani, H., Braun, J. R., Hammer, R. E., & Herz, J. (1996) · The EMBO Journal

Cholesterol and Lipid MetabolismHeat shock proteins research

Cited by 276

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

Ferris, H. A., Perry, R. J., Moreira, G. V., Shulman, G. I., Horton, J. D., & Kahn, C. R. (2017) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 246

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., et al. (2016) · Nature Communications

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 205

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis

Kim, C.-W., Moon, Y.-A., Park, S. W., Cheng, D., Kwon, H. J., & Horton, J. D. (2010) · Proceedings of the National Academy of Sciences

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 136

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

Rong, S., Cortés, V. A., Rashid, S., Anderson, N. N., McDonald, J. G., Liang, G., Moon, Y.-A., Hammer, R. E., & Horton, J. D. (2017) · eLife

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 134

DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER

Rong, S., Xia, M., Vale, G., Wang, S., Kim, C.-W., Li, S., McDonald, J. G., Radhakrishnan, A., & Horton, J. D. (2024) · Cell Metabolism

Lipid metabolism and biosynthesisLiver Disease Diagnosis and Treatment

Cited by 102

Dietary fatty acids regulate hepatic low density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels.

Horton, J. D., Cuthbert, J. A., & Spady, D. K. (1993) · Journal of Clinical Investigation

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 100

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease

Jia, L., Chang, X., Qian, S., Liu, C., Lord, C. C., Ahmed, N., Lee, C. E., Lee, S., Gautron, L., Mitchell, M. C., et al. (2018) · Molecular Metabolism

Alcohol Consumption and Health EffectsLiver Disease Diagnosis and Treatment

Cited by 54