Cited by 1,772Liver Disease Diagnosis and TreatmentLiver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Molecular mediators of hepatic steatosis and liver injury

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Browning, Jeffrey D., Horton, Jay D.·2004·Journal of Clinical Investigation

Abstract

Nonstandard abbreviations used: acetyl-CoA carboxylase (ACC); AMP-activated protein kinase (AMPK); basic helix-loop-helix-leucine zipper (bHLH-Zip); carbohydrate response element binding protein (ChREBP); carnitine palmitoyl transferase-1 (CPT-1); diethylaminoethoxyhexestrol (DEAEH); liver function test (LFT); liver-type pyruvate kinase (L-PK); malondialdehyde (MDA); mitochondrial respiratory chain (MRC); nonalcoholic fatty-liver disease (NAFLD); nonalcoholic steatohepatitis (NASH); polyunsaturated fatty acid (PUFA); reactive oxygen species (ROS); stearoyl-CoA desaturase (SCD); trans-4-hydroxy-2-nonenal (HNE). Conflict of interest:The authors have declared that no conflict of interest exists.

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  • Ectopic triglycerides usually signify the presence of long-chain free fatty acids, which are cytotoxic and believed to interfere with normal insulin signaling leading to insulin resistance.

    “Ectopic triglycerides usually signify the presence of long-chain free fatty acids, which are cytotoxic (15,16) and believed to interfere with normal insulin signaling leading to insulin resistance.”

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  1. Iizuka, K., Bruick, R.K., Liang, G., Horton, J.D., and Uyeda, K. 2004. Deficiency of carbohydrate response element binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc. Nat. Acad. Sci. U. S. A. In press.

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Authors
Browning, J. D., & Horton, J. D.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
Horton, Jay D.
Venue
Journal of Clinical Investigation
Published
2004-07-15
Volume
114
Issue
2
Pages
147-152
ISSN
0021-9738 (ISSN-L)
OpenAlex
W4230280576
Cited by
1,772
References
85
Citations by year
2026: 18 · 2025: 32 · 2024: 45 · 2023: 50 · 2022: 73 · 2021: 72 · 2020: 75 · 2019: 100 · 2018: 104 · 2017: 89 · 2016: 102 · 2015: 109 · 2014: 90 · 2013: 104 · 2012: 103
FWCI
48.64
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
Funders
  • American Liver Foundation
  • National Institutes of Health (HL20948)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
hepatic steatosis, liver injury, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, molecular mediators, lipid metabolism, reactive oxygen species, oxidative stress, mitochondrial dysfunction, lipid peroxidation, acetyl-CoA carboxylase, AMPK, ChREBP, stearoyl-CoA desaturase, polyunsaturated fatty acids, malondialdehyde

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