Aravind, L.

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature

Genomics and Phylogenetic StudiesGenetic Associations and Epidemiology

Cited by 24,216

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 5,836

Classification and evolution of P-loop GTPases and related ATPases

Leipe, D. D., Wolf, Y. I., Koonin, E. V., & Aravind, L. (2002) · Journal of Molecular Biology

RNA and protein synthesis mechanismsGenomics and Phylogenetic Studies

Cited by 1,148

Horizontal gene transfer in prokaryotes: Quantification and classification

Koonin, E. V., Makarova, K. S., & Aravind, L. (2001) · Annual Review of Microbiology

Genomics and Phylogenetic StudiesBacterial Genetics and Biotechnology

Cited by 1,126

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

Pastor, W. A., Aravind, L., & Rao, A. (2013) · Nature Reviews Molecular Cell Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 897

Evolution of Aminoacyl-tRNA Synthetases—Analysis of Unique Domain Architectures and Phylogenetic Trees Reveals a Complex History of Horizontal Gene Transfer Events

Wolf, Y. I., Aravind, L., Grishin, N. V., & Koonin, E. V. (1999) · Genome Research

RNA and protein synthesis mechanismsGenomics and Phylogenetic Studies

Cited by 410

START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins

Ponting, C. P., & Aravind, L. (1999) · Trends in Biochemical Sciences

Lipid Membrane Structure and BehaviorProtein Kinase Regulation and GTPase Signaling

Cited by 398

Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes

Anantharaman, V., & Aravind, L. (2003) · Genome Biology

Bacterial Genetics and BiotechnologyBiochemical and Structural Characterization

Cited by 365

Did DNA replication evolve twice independently?

Leipe, D. D., Aravind, L., & Koonin, E. V. (1999) · Nucleic Acids Research

Origins and Evolution of LifeGenomics and Phylogenetic Studies

Cited by 351

Comparative Genomics, Evolution and Origins of the Nuclear Envelope and Nuclear Pore Complex

Mans, B., Anantharaman, V., Aravind, L., & Koonin, E. V. (2004) · Cell Cycle

Nuclear Structure and FunctionChromosomal and Genetic Variations

Cited by 304

Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease

Zhang, D., Iyer, L. M., He, F., & Aravind, L. (2012) · Frontiers in Genetics

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 244

Monophyly of class I aminoacyl tRNA synthetase, USPA, ETFP, photolyase, and PP‐ATPase nucleotide‐binding domains: implications for protein evolution in the RNA world

Aravind, L., Anantharaman, V., & Koonin, E. V. (2002) · Proteins: Structure, Function, and Bioinformatics

RNA and protein synthesis mechanismsProtein Structure and Dynamics

Cited by 153

Trends in protein evolution inferred from sequence and structure analysis

Aravind, L., Mazumder, R., Vasudevan, S., & Koonin, E. V. (2002) · Current Opinion in Structural Biology

Protein Structure and DynamicsGenomics and Phylogenetic Studies

Cited by 148

Eukaryote-specific Domains in Translation Initiation Factors: Implications for Translation Regulation and Evolution of the Translation System

Aravind, L., & Koonin, E. V. (2000) · Genome Research

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 93

Functional Innovation in the Evolution of the Calcium-Dependent System of the Eukaryotic Endoplasmic Reticulum

Schäffer, D. E., Iyer, L. M., Burroughs, A. M., & Aravind, L. (2020) · Frontiers in Genetics

Protist diversity and phylogenyCalcium signaling and nucleotide metabolism

Cited by 20

Mechanism and evolutionary origins of Alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10

Patil, P. R., Burroughs, A. M., Misra, M., Cerullo, F., Dikic, I., Aravind, L., & Joazeiro, C. A. P. (2023) · Cell Reports

Ubiquitin and proteasome pathwaysRNA and protein synthesis mechanisms

Cited by 20

Systematic identification of Salmonella T6SS effectors uncovers diverse new families and lipid-targeting activities

Nicastro, G. G., Sibinelli-Sousa, S., Hespanhol, J. T., Santos, T. W. C., Munoz, J. P., Santos, R. S., Perez-Sepulveda, B. M., Miyamoto, S., Aravind, L., de Souza, R. F., et al. (2026) · PLOS Biology

Salmonella and Campylobacter epidemiologyBacterial Genetics and Biotechnology

Cited by 9

Genome-directed study reveals the diversity of Salmonella T6SS effectors and identifies a novel family of lipid-targeting antibacterial toxins

Nicastro, G. G., Sibinelli-Sousa, S., Hespanhol, J. T., Santos, T. W. C., Munoz, J. P., Santos, R. S., Perez-Sepulveda, B. M., Miyamoto, S., Aravind, L., de Souza, R. F., et al. (2024) · PLoS Biology

Salmonella and Campylobacter epidemiologyBacterial Genetics and Biotechnology

Cited by 9

Altruistic feeding and cell-cell signaling during bacterial differentiation actively enhance phenotypic heterogeneity

Updegrove, T. B., Delerue, T., Anantharaman, V., Cho, H., Chan, C., Nipper, T., Choo-Wosoba, H., Jenkins, L. M., Zhang, L., Su, Y., et al. (2024) · Science Advances

Bacterial Genetics and BiotechnologyGene Regulatory Network Analysis

Cited by 9

Bacterial cell surface nanoenvironment requires a specialized chaperone to activate a peptidoglycan biosynthetic enzyme

Delerue, T., Chareyre, S., Anantharaman, V., Gilmore, M. C., Popham, D. L., Cava, F., Aravind, L., & Ramamurthi, K. S. (2023) · Proceedings of the National Academy of Sciences

Bacterial Genetics and BiotechnologyHeat shock proteins research

Cited by 4

The lipocone superfamily, a unifying theme in metabolism of lipids, peptidoglycan and exopolysaccharides, inter-organismal conflicts and immunity

Burroughs, A. M., Nicastro, G. G., & Aravind, L. (2025) · eLife

Wnt/β-catenin signaling in development and cancerBacterial Genetics and Biotechnology

Cited by 2