Wu, Dalei

Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans.

Smith, S. H., Jayawickreme, C., Rickard, D. J., Nicodeme, E., Bui, T., Simmons, C., Coquery, C. M., Neil, J., Pryor, W. M., Mayhew, D., et al. (2017) · Journal of Investigative Dermatology

Psoriasis: Treatment and PathogenesisDermatology and Skin Diseases

Cited by 387

Structural integration in hypoxia-inducible factors

Wu, D., Potluri, N., Lu, J., Kim, Y., & Rastinejad, F. (2015) · Nature

Cancer, Hypoxia, and MetabolismEnzyme Structure and Function

Cited by 346

Multidomain integration in the structure of the HNF-4α nuclear receptor complex

Chandra, V., Huang, P., Potluri, N., Wu, D., Kim, Y., & Rastinejad, F. (2013) · Nature

Protein Structure and DynamicsNuclear Receptors and Signaling

Cited by 206

Structural characterization of mammalian bHLH-PAS transcription factors

Wu, D., & Rastinejad, F. (2017) · Current Opinion in Structural Biology

Protein Structure and DynamicsCircadian rhythm and melatonin

Cited by 122

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

Wu, D., Su, X., Potluri, N., Kim, Y., & Rastinejad, F. (2016) · eLife

Genomics and Chromatin DynamicsProtein Structure and Dynamics

Cited by 85

Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex

Diao, X., Shang, Q., Guo, M., Huang, Y., Zhang, M., Chen, X., Liang, Y., Sun, X., Zhou, F., Zhuang, J., et al. (2025) · Nature communications

Toxic Organic Pollutants ImpactProtein Structure and Dynamics

Cited by 72

Identification of oleoylethanolamide as an endogenous ligand for HIF-3α

Diao, X., Ye, F., Zhang, M., Ren, X., Tian, X., Lu, J., Sun, X., Hou, Z., Chen, X., Li, F., et al. (2022) · Nature Communications

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 51

Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family

Sun, X., Jing, L., Li, F., Zhang, M., Diao, X., Zhuang, J., Rastinejad, F., & Wu, D. (2022) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 32