Ward, Michael E.

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

Shi, Y., Lin, S., Staats, K. A., Li, Y., Chang, W.-H., Hung, S.-T., Hendricks, E., Linares, G. R., Wang, Y., Son, E. Y., et al. (2018) · Nature Medicine

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 566

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

Liao, Y.-C., Fernandopulle, M. S., Wang, G., Choi, H., Hao, L., Drerup, C. M., Patel, R., Qamar, S., Nixon-Abell, J., Shen, Y., et al. (2019) · Cell

RNA Research and SplicingCellular transport and secretion

Cited by 550

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

Wang, S., Mustafa, M., Yuede, C. M., Salazar, S. V., Kong, P., Long, H., Ward, M., Siddiqui, O., Paul, R., Gilfillan, S., et al. (2020) · Journal of Experimental Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 549

CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

Tian, R., Gachechiladze, M. A., Ludwig, C. H., Laurie, M. T., Hong, J. Y., Nathaniel, D., Prabhu, A. V., Fernandopulle, M. S., Patel, R., Abshari, M., et al. (2019) · Neuron

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

Cited by 543

Transcription factor-mediated differentiation of human iPSCs into neurons

Fernandopulle, M. S., Prestil, R., Grunseich, C., Wang, C., Gan, L., & Ward, M. E. (2018) · Current Protocols in Cell Biology

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 461

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

Wang, C., Ward, M. E., Chen, R., Liu, K., Tracy, T. E., Chen, X., Xie, M., Sohn, P. D., Ludwig, C., Meyer-Franke, A., et al. (2017) · Stem Cell Reports

Pluripotent Stem Cells ResearchAlzheimer's disease research and treatments

Cited by 400

A reference human induced pluripotent stem cell line for large-scale collaborative studies

Pantazis, C. B., Yang, A., Lara, E., McDonough, J. A., Blauwendraat, C., Peng, L., Oguro, H., Kanaujiya, J., Zou, J., Sebesta, D., et al. (2022) · Cell Stem Cell

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 310

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states

Dräger, N. M., Sattler, S. M., Huang, C. T.-L., Teter, O. M., Leng, K., Hashemi, S. H., Hong, J., Aviles, G., Clelland, C. D., Zhan, L., et al. (2022) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsPluripotent Stem Cells Research

Cited by 258

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

Minami, S. S., Min, S.-W., Krabbe, G., Wang, C., Zhou, Y., Asgarov, R., Li, Y., Martens, L. H., Elia, L. P., Ward, M. E., et al. (2014) · Nature Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 237

Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia

Prudencio, M., Humphrey, J., Pickles, S., Brown, A.-L., Hill, S. E., Kachergus, J. M., Shi, J., Heckman, M. G., Spiegel, M. R., Cook, C., et al. (2020) · Journal of Clinical Investigation

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 231

Neuronal enhancers are hotspots for DNA single-strand break repair

Wu, W., Kargbo-Hill, S. E., Nathan, W. J., Paiano, J., Callen, E., Wang, D., Shinoda, K., van Wietmarschen, N., Colón-Mercado, J. M., Zong, D., et al. (2021) · Nature

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 223

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis

Ward, M. E., Chen, R., Huang, H.-Y., Ludwig, C., Telpoukhovskaia, M., Taubes, A., Boudin, H., Minami, S. S., Reichert, M., Albrecht, P., et al. (2017) · Science Translational Medicine

Lysosomal Storage Disorders ResearchAmyotrophic Lateral Sclerosis Research

Cited by 193

RNA transport and local translation in neurodevelopmental and neurodegenerative disease

Fernandopulle, M. S., Lippincott-Schwartz, J., & Ward, M. E. (2021) · Nature Neuroscience

RNA Research and SplicingGenetics and Neurodevelopmental Disorders

Cited by 183

Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

Sarraf, S. A., Shah, H. V., Kanfer, G., Pickrell, A. M., Holtzclaw, L. A., Ward, M. E., & Youle, R. J. (2020) · Molecular Cell

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 143

The Alzheimer's Prevention Initiative Autosomal‐Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal‐dominant Alzheimer's disease, including a placebo‐treated noncarrier cohort

Tariot, P. N., Lopera, F., Langbaum, J. B., Thomas, R. G., Hendrix, S., Schneider, L. S., Rios‐Romenets, S., Giraldo, M., Acosta, N., Tobon, C., et al. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 128

Active DNA demethylation promotes cell fate specification and the DNA damage response

Wang, D., Wu, W., Callen, E., Pavani, R., Zolnerowich, N., Kodali, S., Zong, D., Wong, N., Noriega, S., Nathan, W. J., et al. (2022) · Science

DNA Repair MechanismsEpigenetics and DNA Methylation

Cited by 113

Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

De Pace, R., Ghosh, S., Ryan, V. H., Sohn, M., Jarnik, M., Rezvan Sangsari, P., Morgan, N. Y., Dale, R. K., Ward, M. E., & Bonifacino, J. S. (2024) · Nature Neuroscience

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 81

Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4

Stephenson, R. A., Sepulveda, J., Johnson, K. R., Lita, A., Gopalakrishnan, J., Acri, D. J., Beilina, A., Cheng, L., Yang, L. G., Root, J. T., et al. (2025) · Cell Reports

Neuroinflammation and Neurodegeneration MechanismsLipid metabolism and biosynthesis

Cited by 55

Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology

de Majo, M., Koontz, M., Marsan, E., Salinas, N., Ramsey, A., Kuo, Y.-M., Seo, K., Li, H., Dräger, N., Leng, K., et al. (2023) · Stem Cell Reports

Amyotrophic Lateral Sclerosis ResearchPluripotent Stem Cells Research

Cited by 44

Deficiency of the Lysosomal Protein CLN5 Alters Lysosomal Function and Movement

Basak, I., Hansen, R. A., Ward, M. E., & Hughes, S. M. (2021) · Biomolecules

Lysosomal Storage Disorders ResearchGlycogen Storage Diseases and Myoclonus

Cited by 23

INVOKE‐2: A phase 2 randomized, double‐blind, placebo‐controlled study to evaluate the efficacy and safety of AL002 in participants with early Alzheimer’s disease

Paul, R., Jackson, S., Ward, M., Joshi, A., Castro, A., Yeh, F. L., Liao, Y., & Morrison, G. (2021) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 10