Robbins, Nicole

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 801

Regulatory circuitry governing fungal development, drug resistance, and disease.

Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011) · Microbiology and Molecular Biology Reviews

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 576

Molecular Evolution of Antifungal Drug Resistance

Robbins, N., Caplan, T., & Cowen, L. E. (2017) · Annual Review of Microbiology

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 441

Treatment strategies for cryptococcal infection: challenges, advances and future outlook

Iyer, K. R., Revie, N. M., Fu, C., Robbins, N., & Cowen, L. E. (2021) · Nature Reviews Microbiology

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 363

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

Singh, S. D., Robbins, N., Zaas, A. K., Schell, W. A., Perfect, J. R., & Cowen, L. E. (2009) · PLoS Pathogens

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 362

Molecular mechanisms governing antifungal drug resistance

Lee, Y., Robbins, N., & Cowen, L. E. (2023) · npj Antimicrobials and Resistance

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 304

Hsp90 Governs Dispersion and Drug Resistance of Fungal Biofilms

Robbins, N., Uppuluri, P., Nett, J., Rajendran, R., Ramage, G., Lopez-Ribot, J. L., Andes, D., & Cowen, L. E. (2011) · PLoS Pathogens

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 291

Antifungal Drugs: The Current Armamentarium and Development of New Agents

Robbins, N., Wright, G. D., & Cowen, L. E. (2016) · Microbiology Spectrum

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 271

Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance

Kim, S. H., Iyer, K. R., Pardeshi, L., Muñoz, J. F., Robbins, N., Cuomo, C. A., Wong, K. H., & Cowen, L. E. (2019) · mBio

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 136

Lysine Deacetylases Hda1 and Rpd3 Regulate Hsp90 Function thereby Governing Fungal Drug Resistance

Robbins, N., Leach, M. D., & Cowen, L. E. (2012) · Cell Reports

Heat shock proteins researchFungal and yeast genetics research

Cited by 126

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Whitesell, L., Robbins, N., Huang, D. S., McLellan, C. A., Shekhar-Guturja, T., LeBlanc, E. V., Nation, C. S., Hui, R., Hutchinson, A., Collins, C., et al. (2019) · Nature Communications

Heat shock proteins researchAntifungal resistance and susceptibility

Cited by 124

The Hsp90 chaperone network modulates Candida virulence traits

O’Meara, T. R., Robbins, N., & Cowen, L. E. (2017) · Trends in Microbiology

Heat shock proteins researchFungal and yeast genetics research

Cited by 92

The role of Candida albicans stress response pathways in antifungal tolerance and resistance

Iyer, K. R., Robbins, N., & Cowen, L. E. (2022) · iScience

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 88

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens

Robbins, N., Spitzer, M., Yu, T., Cerone, R. P., Averette, A. K., Bahn, Y.-S., Heitman, J., Sheppard, D. C., Tyers, M., & Wright, G. D. (2015) · Cell Reports

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 78

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

Xie, J. L., Qin, L., Miao, Z., Grys, B. T., Diaz, J. D. L. C., Ting, K., Krieger, J. R., Tong, J., Tan, K., Leach, M. D., et al. (2017) · Nature Communications

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 60

Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2

Caplan, T., Lorente-Macías, Á., Stogios, P. J., Evdokimova, E., Hyde, S., Wellington, M. A., Liston, S., Iyer, K. R., Puumala, E., Shekhar-Guturja, T., et al. (2020) · Cell Chemical Biology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 57

Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans

Caplan, T., Polvi, E. J., Xie, J. L., Buckhalter, S., Leach, M. D., Robbins, N., & Cowen, L. E. (2018) · Cell Reports

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 56

Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space

Veri, A. O., Miao, Z., Shapiro, R. S., Tebbji, F., O’Meara, T. R., Kim, S. H., Colazo, J., Tan, K., Vyas, V. K., Whiteway, M., et al. (2018) · PLoS Genetics

Fungal and yeast genetics researchHeat shock proteins research

Cited by 51

Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function

Robbins, N., Spitzer, M., Wang, W., Waglechner, N., Patel, D. J., O’Brien, J. S., Ejim, L., Ejim, O., Tyers, M., & Wright, G. D. (2016) · Cell Chemical Biology

Microbial Natural Products and BiosynthesisFungal Infections and Studies

Cited by 41

Fungal-selective resorcylate aminopyrazole Hsp90 inhibitors: optimization of whole-cell anticryptococcal activity and insights into the structural origins of cryptococcal selectivity

Marcyk, P. T., LeBlanc, E. V., Kuntz, D. A., Xue, A., Ortiz, F., Trilles, R., Bengtson, S., Kenney, T. M. G., Huang, D. S., Robbins, N., et al. (2021) · Journal of Medicinal Chemistry

Heat shock proteins researchFungal Infections and Studies

Cited by 40

Metabolic control of antifungal drug resistance

Robbins, N., Collins, C., Morhayim, J., & Cowen, L. E. (2010) · Fungal Genetics and Biology

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 40

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs

Mount, H. O., Revie, N. M., Todd, R. T., Anstett, K., Collins, C., Costanzo, M., Boone, C., Robbins, N., Selmecki, A., & Cowen, L. E. (2018) · PLOS Genetics

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 34

Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence

Fu, C., Beattie, S. R., Jezewski, A. J., Robbins, N., Whitesell, L., Krysan, D. J., & Cowen, L. E. (2022) · Genetics

Fungal Infections and StudiesHeat shock proteins research

Cited by 31

Erratum for Kim et al., “Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance”

Kim, S. H., Iyer, K. R., Pardeshi, L., Muñoz, J. F., Robbins, N., Cuomo, C. A., Wong, K. H., & Cowen, L. E. (2019) · mBio

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 28