Webber, Caleb

Genome sequence, comparative analysis and haplotype structure of the domestic dog

members, B. S. P., Lindblad-Toh, K., Wade, C. M., Mikkelsen, T. S., Karlsson, E. K., Jaffe, D. B., Kamal, M., Clamp, M., Chang, J. L., Kulbokas, E. J., et al. (2005) · Nature

Human-Animal Interaction StudiesGenetic and phenotypic traits in livestock

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Functional impact of global rare copy number variation in autism spectrum disorders

Pinto, D., Pagnamenta, A. T., Klei, L., Anney, R., Merico, D., Regan, R., Conroy, J., Magalhaes, T. R., Correia, C., Abrahams, B. S., et al. (2010) · Nature

Autism Spectrum Disorder ResearchGenomic variations and chromosomal abnormalities

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Analysis of shared heritability in common disorders of the brain

The Brainstorm Consortium, Anttila, V., Bulik-Sullivan, B., Finucane, H. K., Walters, R. K., Bras, J., Duncan, L., Escott-Price, V., Falcone, G. J., Gormley, P., et al. (2018) · Science

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

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Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences

Broad Institute Genome Sequencing Platform, Mikkelsen, T. S., Broad Institute Whole Genome Assembly Team, Wakefield, M. J., Aken, B., Amemiya, C. T., Chang, J. L., Duke, S., Garber, M., Gentles, A. J., et al. (2007) · Nature

Chromosomal and Genetic VariationsGenomics and Phylogenetic Studies

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Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility

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Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Mancuso, R., Fryatt, G., Cleal, M., Obst, J., Pipi, E., Monzón-Sandoval, J., Ribe, E., Winchester, L., Webber, C., Nevado, A., et al. (2019) · Brain

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

Volpato, V., Smith, J., Sandor, C., Ried, J. S., Baud, A., Handel, A., Newey, S. E., Wessely, F., Attar, M., Whiteley, E., et al. (2018) · Stem Cell Reports

Pluripotent Stem Cells ResearchSingle-cell and spatial transcriptomics

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A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease

Tsartsalis, S., Sleven, H., Fancy, N., Wessely, F., Smith, A. M., Willumsen, N., Cheung, T. K. D., Rokicki, M. J., Chau, V., Ifie, E., et al. (2024) · Nature Communications

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

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The Parkinson's Disease Genome‐Wide Association Study Locus Browser

Grenn, F. P., Kim, J. J., Makarious, M. B., Iwaki, H., Illarionova, A., Brolin, K., Kluss, J. H., Schumacher‐Schuh, A. F., Leonard, H., Faghri, F., et al. (2020) · Movement Disorders

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The Roles of FMRP-Regulated Genes in Autism Spectrum Disorder: Single- and Multiple-Hit Genetic Etiologies

Steinberg, J., & Webber, C. (2013) · The American Journal of Human Genetics

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

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An analysis of the gene complement of a marsupial,Monodelphis domestica: Evolution of lineage-specific genes and giant chromosomes

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Chromosomal and Genetic VariationsGenomics and Phylogenetic Studies

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TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

Hall-Roberts, H., Agarwal, D., Obst, J., Smith, T. B., Monzón-Sandoval, J., Di Daniel, E., Webber, C., James, W. S., Mead, E., Davis, J. B., et al. (2020) · Alzheimer's Research & Therapy

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Network Topologies and Convergent Aetiologies Arising from Deletions and Duplications Observed in Individuals with Autism

Noh, H. J., Ponting, C. P., Boulding, H. C., Meader, S., Betancur, C., Buxbaum, J. D., Pinto, D., Marshall, C. R., Lionel, A. C., Scherer, S. W., et al. (2013) · PLoS Genetics

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

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Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer’s disease mouse models

Monzón-Sandoval, J., Burlacu, E., Agarwal, D., Handel, A. E., Wei, L., Davis, J., Cowley, S. A., Cader, M. Z., & Webber, C. (2022) · Disease Models & Mechanisms

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Demultiplexing of single-cell RNA-sequencing data using interindividual variation in gene expression

Nassiri, I., Kwok, A. J., Bhandari, A., Bull, K. R., Garner, L. C., Klenerman, P., Webber, C., Parkkinen, L., Lee, A. W., Wu, Y., et al. (2024) · Bioinformatics Advances

Single-cell and spatial transcriptomicsGene expression and cancer classification

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