Wiest, Olaf

Selective inhibition of BET bromodomains

Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W. B., Fedorov, O., Morse, E. M., Keates, T., Hickman, T. T., Felletar, I., et al. (2010) · Nature

Protein Degradation and InhibitorsChromatin Remodeling and Cancer

Cited by 4,262

Large Language Model based Multi-Agents: A Survey of Progress and Challenges

Guo, T., Chen, X., Wang, Y., Chang, R., Pei, S., Chawla, N. V., Wiest, O., & Zhang, X. (2024) · arXiv

Multi-Agent Systems and NegotiationAI-based Problem Solving and Planning

Cited by 1,713

Inhibition of histone deacetylases: A pharmacological approach to the treatment of non-cancer disorders

Wiech, N., Fisher, J., Helquist, P., & Wiest, O. (2009) · Current Topics in Medicinal Chemistry

Histone Deacetylase Inhibitors ResearchEpigenetics and DNA Methylation

Cited by 66

Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8

Decroos, C., Clausen, D. J., Haines, B. E., Wiest, O., Williams, R. M., & Christianson, D. W. (2015) · Biochemistry

Histone Deacetylase Inhibitors ResearchEnzyme Structure and Function

Cited by 58

On the Structure and Dynamics of Duplex GNA

Johnson, A. T., Schlegel, M. K., Meggers, E., Essen, L.-O., & Wiest, O. (2011) · The Journal of Organic Chemistry

DNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

Cited by 28

Microsecond timescale MD simulations at the transition state of Pm HMGR predict remote allosteric residues

Quinn, T. R., Steussy, C. N., Haines, B. E., Lei, J., Wang, W., Sheong, F. K., Stauffacher, C. V., Huang, X., Norrby, P.-O., Helquist, P., et al. (2021) · Chemical Science

Protein Structure and DynamicsPhysical Organic Chemistry and Reaction Kinetics

Cited by 12

LLMs4All: A Review of Large Language Models Across Academic Disciplines

Ye, Y., Zhang, Z., Ma, T., Wang, Z., Li, Y., Hou, S., Sun, W., Shi, K., Ma, Y., Song, W., et al. (2025) · arXiv

Topic ModelingArtificial Intelligence Applications

Cited by 8