Gosselin, David

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

Gosselin, D., Link, V. M., Romanoski, C. E., Fonseca, G. J., Eichenfield, D. Z., Spann, N. J., Stender, J. D., Chun, H. B., Garner, H., Geissmann, F., et al. (2014) · Cell

Genomics and Chromatin DynamicsImmune cells in cancer

Cited by 1,307

An environment-dependent transcriptional network specifies human microglia identity

Gosselin, D., Skola, D., Coufal, N. G., Holtman, I. R., Schlachetzki, J. C. M., Sajti, E., Jaeger, B. N., O’Connor, C., Fitzpatrick, C., Pasillas, M. P., et al. (2017) · Science

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 1,220

Brain cell type–specific enhancer–promoter interactome maps and disease - risk association

Nott, A., Holtman, I. R., Coufal, N. G., Schlachetzki, J. C. M., Yu, M., Hu, R., Han, C. Z., Pena, M., Xiao, J., Wu, Y., et al. (2019) · Science

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 699

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

Lam, M. T. Y., Cho, H., Lesch, H. P., Gosselin, D., Heinz, S., Tanaka-Oishi, Y., Benner, C., Kaikkonen, M. U., Kim, A. S., Kosaka, M., et al. (2013) · Nature

Genomics and Chromatin DynamicsCancer-related molecular mechanisms research

Cited by 548

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

Seidman, J. S., Troutman, T. D., Sakai, M., Gola, A., Spann, N. J., Bennett, H., Bruni, C. M., Ouyang, Z., Li, R. Z., Sun, X., et al. (2020) · Immunity

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 443

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

Crotti, A., Benner, C., Kerman, B. E., Gosselin, D., Lagier-Tourenne, C., Zuccato, C., Cattaneo, E., Gage, F. H., Cleveland, D. W., & Glass, C. K. (2014) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsGenetic Neurodegenerative Diseases

Cited by 333

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

Schafer, S. T., Paquola, A. C. M., Stern, S., Gosselin, D., Ku, M., Pena, M., Kuret, T. J. M., Liyanage, M., Mansour, A. A., Jaeger, B. N., et al. (2019) · Nature Neuroscience

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 288

MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation

Gosselin, D., & Rivest, S. (2008) · Molecular Psychiatry

Neuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

Cited by 109

Cx3cr1- deficient microglia exhibit a premature aging transcriptome

Gyoneva, S., Hosur, R., Gosselin, D., Zhang, B., Ouyang, Z., Cotleur, A. C., Peterson, M., Allaire, N., Challa, R., Cullen, P., et al. (2019) · Life Science Alliance

Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 103

SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity

Fixsen, B. R., Han, C. Z., Zhou, Y., Spann, N. J., Saisan, P., Shen, Z., Balak, C., Sakai, M., Cobo, I., Holtman, I. R., et al. (2023) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsTGF-β signaling in diseases

Cited by 87

Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis

Chignon, A., Rosa, M., Boulanger, M.-C., Argaud, D., Devillers, R., Bon-Baret, V., Mkannez, G., Li, Z., Rufiange, A., Gaudreault, N., et al. (2021) · iScience

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 18

Epigenomic and transcriptional determinants of microglial cell identity

Gosselin, D. (2020) · Glia

Neuroinflammation and Neurodegeneration MechanismsGenomics and Chromatin Dynamics

Cited by 7