Helleday, Thomas

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature

PARP inhibition in cancer therapyDNA Repair Mechanisms

Cited by 5,198

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 1,986

DNA repair pathways as targets for cancer therapy

Helleday, T., Petermann, E., Lundin, C., Hodgson, B., & Sharma, R. A. (2008) · Nature Reviews Cancer

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 1,666

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Sørensen, C. S., Hansen, L. T., Dziegielewski, J., Syljuåsen, R. G., Lundin, C., Bartek, J., & Helleday, T. (2005) · Nature Cell Biology

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 666

DNA double-strand break repair: From mechanistic understanding to cancer treatment

HELLEDAY, T., LO, J., VANGENT, D., & ENGELWARD, B. (2007) · DNA Repair

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 640

Pathways of mammalian replication fork restart

Petermann, E., & Helleday, T. (2010) · Nature Reviews Molecular Cell Biology

DNA Repair MechanismsBacterial Genetics and Biotechnology

Cited by 340

Chk1 promotes replication fork progression by controlling replication initiation

Petermann, E., Woodcock, M., & Helleday, T. (2010) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsMicrotubule and mitosis dynamics

Cited by 308

Identification of the MMS22L-TONSL Complex that Promotes Homologous Recombination

Duro, E., Lundin, C., Ask, K., Sanchez-Pulido, L., MacArtney, T. J., Toth, R., Ponting, C. P., Groth, A., Helleday, T., & Rouse, J. (2010) · Molecular Cell

DNA Repair MechanismsFungal and yeast genetics research

Cited by 125

RAD51 is involved in repair of damage associated with DNA replication in mammalian cells

Lundin, C., Schultz, N., Arnaudeau, C., Mohindra, A., Hansen, L. T., & Helleday, T. (2003) · Journal of Molecular Biology

DNA Repair MechanismsEffects of Radiation Exposure

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Global survey of the immunomodulatory potential of common drugs

Vladimer, G. I., Snijder, B., Krall, N., Bigenzahn, J. W., Huber, K. V. M., Lardeau, C.-H., Sanjiv, K., Ringler, A., Berglund, U. W., Sabler, M., et al. (2017) · Nature Chemical Biology

Cancer Immunotherapy and BiomarkersImmunotoxicology and immune responses

Cited by 87

NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis

Huang, B., Lyu, Z., Qian, Q., Chen, Y., Zhang, J., Li, B., Li, Y., Liang, J., Liu, Q., Li, Y., et al. (2022) · Journal of Hepatology

Liver Diseases and ImmunityT-cell and B-cell Immunology

Cited by 60