Cited by 1,666DNA Repair MechanismsPARP inhibition in cancer therapyCancer therapeutics and mechanisms

DNA repair pathways as targets for cancer therapy

Helleday, Thomas, Petermann, Eva, Lundin, Cecilia, Hodgson, Ben, Sharma, Ricky A.·2008·Nature Reviews Cancer

Abstract

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/nrc2342

Cites

229 of 229 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Helleday, T., Petermann, E., Lundin, C., Hodgson, B., & Sharma, R. A.
Affiliations
University of Oxford (GB)
Corresponding author
Helleday, Thomas
Venue
Nature Reviews Cancer
Published
2008-03
Volume
8
Issue
3
Pages
193-204
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W1976385056
Cited by
1,666
References
229
Citations by year
2026: 39 · 2025: 71 · 2024: 71 · 2023: 95 · 2022: 97 · 2021: 105 · 2020: 97 · 2019: 94 · 2018: 109 · 2017: 108 · 2016: 117 · 2015: 113 · 2014: 105 · 2013: 93 · 2012: 99
FWCI
6.59
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders
Cancer Research UK
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer therapeutics and mechanisms
Keywords
DNA repair pathways, cancer therapy, DNA-damaging chemotherapy, chemoresistance, DNA repair inhibitors, combination therapy, monotherapy, tumor cell survival, targeted cancer therapy
MeSH terms
Animals, Antineoplastic Agents, Cell Survival, DNA Damage, DNA Repair, Humans, Medical Oncology, Models, Biological, Neoplasms, Treatment Outcome, DNA Repair Enzymes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review