DNA repair pathways as targets for cancer therapy
Abstract
DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects.
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Defects in DNA repair and DNA damage response pathways can lead to human diseases such as cancer and neurodegenerative diseases.
“Defective DNA repair and DDR pathways may lead to several human diseases, such as cancer and neurodegenerative diseases [6, 33–38]”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [36]
Defects in DNA repair and DDR pathways are associated with cancer and neurodegenerative diseases.
“Dysfunctions in these pathways are linked to cancer and neurodegenerative diseases [6, 33–38]”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [36]
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- Authors
- Helleday, T., Petermann, E., Lundin, C., Hodgson, B., & Sharma, R. A.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Helleday, Thomas
- Venue
- Nature Reviews Cancer
- Published
- 2008-03
- Volume
- 8
- Issue
- 3
- Pages
- 193-204
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1976385056
- Cited by
- 1,666
- References
- 229
- Citations by year
- 2026: 39 · 2025: 71 · 2024: 71 · 2023: 95 · 2022: 97 · 2021: 105 · 2020: 97 · 2019: 94 · 2018: 109 · 2017: 108 · 2016: 117 · 2015: 113 · 2014: 105 · 2013: 93 · 2012: 99
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Cancer Research UK
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer therapeutics and mechanisms
- Keywords
- DNA repair pathways, cancer therapy, DNA-damaging chemotherapy, chemoresistance, DNA repair inhibitors, combination therapy, monotherapy, tumor cell survival, targeted cancer therapy
- MeSH terms
- Animals, Antineoplastic Agents, Cell Survival, DNA Damage, DNA Repair, Humans, Medical Oncology, Models, Biological, Neoplasms, Treatment Outcome, DNA Repair Enzymes
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