Saul, Dominik

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Saul, D., Kosinsky, R. L., Atkinson, E. J., Doolittle, M. L., Zhang, X., LeBrasseur, N. K., Pignolo, R. J., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Nature Communications

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,022

Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence

Saul, D., & Khosla, S. (2022) · Endocrine Reviews

Bone fractures and treatmentsBone health and osteoporosis research

Cited by 185

Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial

Farr, J. N., Atkinson, E. J., Achenbach, S. J., Volkman, T. L., Tweed, A. J., Vos, S. J., Ruan, M., Sfeir, J., Drake, M. T., Saul, D., et al. (2024) · Nature Medicine

Telomeres, Telomerase, and SenescenceBone health and osteoporosis research

Cited by 127

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

Farr, J. N., Saul, D., Doolittle, M. L., Kaur, J., Rowsey, J. L., Vos, S. J., Froemming, M. N., Lagnado, A. B., Zhu, Y., Weivoda, M., et al. (2023) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 81

Modulation of fracture healing by the transient accumulation of senescent cells

Saul, D., Monroe, D. G., Rowsey, J. L., Kosinsky, R. L., Vos, S. J., Doolittle, M. L., Farr, J. N., & Khosla, S. (2021) · eLife

Telomeres, Telomerase, and SenescenceBone fractures and treatments

Cited by 71

Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

Doolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D. G., & Khosla, S. (2023) · Nature Communications

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 57

Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

Doolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D. G., & Khosla, S. (2023) · Nature Communications

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 57

Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues

Saul, D., Jurk, D., Doolittle, M. L., Kosinsky, R. L., Han, Y., Zhang, X., Franco, A. C., Kim, S. Y., Wyles, S. P., Prakash, Y. S., et al. (2025) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 45

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

Samakkarnthai, P., Saul, D., Zhang, L., Aversa, Z., Doolittle, M. L., Sfeir, J. G., Kaur, J., Atkinson, E. J., Edwards, J. R., Russell, G. G., et al. (2023) · Aging

Telomeres, Telomerase, and SenescenceBone health and treatments

Cited by 34

Distinct secretomes in p16- and p21- positive senescent cells across tissues

Saul, D., Jurk, D., Doolittle, M. L., Kosinsky, R. L., Monroe, D. G., LeBrasseur, N. K., Robbins, P. D., Niedernhofer, L. J., Khosla, S., & Passos, J. F. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 28

Evolutionary analysis reveals the role of a non-catalytic domain of peptidyl arginine deiminase 2 in transcriptional regulation

Villanueva-Cañas, J. L., Fernandez-Fuentes, N., Saul, D., Kosinsky, R. L., Teyssier, C., Rogalska, M. E., Pérez, F. P., Oliva, B., Notredame, C., Beato, M., et al. (2022) · iScience

Cancer-related gene regulationGenomics and Chromatin Dynamics

Cited by 6