Helm, Dominic

The target landscape of clinical kinase drugs

Klaeger, S., Heinzlmeir, S., Wilhelm, M., Polzer, H., Vick, B., Koenig, P.-A., Reinecke, M., Ruprecht, B., Petzoldt, S., Meng, C., et al. (2017) · Science

Computational Drug Discovery MethodsAdvanced Proteomics Techniques and Applications

Cited by 854

The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice

Kindt, A., Liebisch, G., Clavel, T., Haller, D., Hörmannsperger, G., Yoon, H., Kolmeder, D., Sigruener, A., Krautbauer, S., Seeliger, C., et al. (2018) · Nature Communications

Gut microbiota and healthLipid metabolism and biosynthesis

Cited by 311

Thermal proteome profiling for interrogating protein interactions

Mateus, A., Kurzawa, N., Becher, I., Sridharan, S., Helm, D., Stein, F., Typas, A., & Savitski, M. M. (2020) · Molecular Systems Biology

Advanced Proteomics Techniques and Applicationsthermodynamics and calorimetric analyses

Cited by 258

A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver

Inverso, D., Shi, J., Lee, K. H., Jakab, M., Ben-Moshe, S., Kulkarni, S. R., Schneider, M., Wang, G., Komeili, M., Vélez, P. A., et al. (2021) · Developmental Cell

Single-cell and spatial transcriptomicsLiver physiology and pathology

Cited by 114

Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs

Heinzlmeir, S., Kudlinzki, D., Sreeramulu, S., Klaeger, S., Gande, S. L., Linhard, V., Wilhelm, M., Qiao, H., Helm, D., Ruprecht, B., et al. (2016) · ACS Chemical Biology

Computational Drug Discovery MethodsProtein Kinase Regulation and GTPase Signaling

Cited by 56

Aggregation and disaggregation features of the human proteome

Määttä, T. A., Rettel, M., Sridharan, S., Helm, D., Kurzawa, N., Stein, F., & Savitski, M. M. (2020) · Molecular Systems Biology

Heat shock proteins researchAdvanced Proteomics Techniques and Applications

Cited by 34

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis

Lim, B., Kamal, A., Gomez Ramos, B., Adrian Segarra, J. M., Ibarra, I. L., Dignas, L., Kindinger, T., Volz, K., Rahbari, M., Rahbari, N., et al. (2025) · Nature Genetics

Liver physiology and pathologyPluripotent Stem Cells Research

Cited by 17

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumourigenesis

Lim, B., Kamal, A., Gomez Ramos, B., Adrian Segarra, J., Ibarra, I., Dignas, L., Kindinger, T., Volz, K., Rahbari, M., Rahbari, N., et al. (2024) · Nature Genetics

Liver physiology and pathologyPluripotent Stem Cells Research

Cited by 17

An atlas of RNA-dependent proteins in cell division reveals the riboregulation of mitotic protein-protein interactions

Rajagopal, V., Seiler, J., Nasa, I., Cantarella, S., Theiss, J., Herget, F., Kaifer, B., Schneider, M., Helm, D., König, J., et al. (2024) · Nature Communications

Microtubule and mitosis dynamicsRNA Research and Splicing

Cited by 15

Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma

Umbaugh, C. S., Groth, M., Erkut, C., Lee, K.-S., Marinho, J., Linder, S., Iser, F., Kapp, J. N., Schroeter, P., Dolaner, S., et al. (2025) · Science Advances

Bone Tumor Diagnosis and TreatmentsProtein Degradation and Inhibitors

Cited by 6