The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice
Open accessAbstract
Interactions between the gut microbial ecosystem and host lipid homeostasis are highly relevant to host physiology and metabolic diseases. We present a comprehensive multi-omics view of the effect of intestinal microbial colonization on hepatic lipid metabolism, integrating transcriptomic, proteomic, phosphoproteomic, and lipidomic analyses of liver and plasma samples from germfree and specific pathogen-free mice. Microbes induce monounsaturated fatty acid generation by stearoyl-CoA desaturase 1 and polyunsaturated fatty acid elongation by fatty acid elongase 5, leading to significant alterations in glycerophospholipid acyl-chain profiles. A composite classification score calculated from the observed alterations in fatty acid profiles in germfree mice clearly differentiates antibiotic-treated mice from untreated controls with high sensitivity. Mechanistic investigations reveal that acetate originating from gut microbial degradation of dietary fiber serves as precursor for hepatic synthesis of C16 and C18 fatty acids and their related glycerophospholipid species that are also released into the circulation.
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The gut microbiota induces hepatic production of monounsaturated fatty acids and elongation of PUFA, and acetate produced by the gut microbiota is used as precursor in hepatic fatty acid synthesis.
“Comparisons between CONV-R and GF mice have also shown that the gut microbiota induces hepatic production of monounsaturated fatty acids and elongation of PUFA, and that acetate produced by the gut microbiota is used as precursor in hepatic fatty acid synthesis [32].”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [32]
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Dietary lipids, gut microbiota and lipid metabolism
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- Authors
- Kindt, A., Liebisch, G., Clavel, T., Haller, D., Hörmannsperger, G., Yoon, H., Kolmeder, D., Sigruener, A., Krautbauer, S., Seeliger, C., Ganzha, A., Schweizer, S., Morisset, R., Strowig, T., Daniel, H., Helm, D., Küster, B., Krumsiek, J., & Ecker, J.
- Affiliations
- Leiden University (NL)
- University Hospital Regensburg (DE)
- Universitätsklinikum Aachen (DE)
- Technical University of Munich (DE)
- Helmholtz Centre for Infection Research (DE)
- Helmholtz Munich (DE)
- Corresponding author
- Krumsiek, Jan
- Ecker, Josef
- ORCID
- Venue
- Nature Communications
- Published
- 2018-09-14
- Volume
- 9
- Issue
- 1
- Pages
- 3760-3760
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6138742
- OpenAlex
- W2891610979
- Cited by
- 311
- References
- 76
- Citations by year
- 2026: 25 · 2025: 37 · 2024: 35 · 2023: 39 · 2022: 46 · 2021: 84 · 2020: 26 · 2019: 17 · 2018: 2
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- HZI (Helmholtz Centre for Infection Research) (submittedVersion, cc-by-nc-sa)
- mediaTUM (Technical University of Munich) (submittedVersion, other-oa)
- RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- RWTH Publications (RWTH Aachen)
- Funders
- Deutsche Forschungsgemeinschaft (LI 923/4-1, STR 1343/2, EC 453/1-1, EC 453/2-1)
- EC | Seventh Framework Programme (613979, 305280)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- gut microbiota, hepatic lipid metabolism, fatty acid desaturation, fatty acid elongation, stearoyl-CoA desaturase 1, monounsaturated fatty acids, polyunsaturated fatty acids, glycerophospholipids, acetate, dietary fiber degradation, germ-free mice, antibiotic therapy, lipidomics, phosphoproteomics, transcriptomics, plasma lipids
- MeSH terms
- Gastrointestinal Microbiome, Fatty Acid Elongases, Acetates, Acetyltransferases, Animals, Dietary Fiber, Fatty Acids, Fatty Acids, Monounsaturated, Fatty Acids, Unsaturated, Germ-Free Life, Liver, Stearoyl-CoA Desaturase, Gene Expression Profiling, Proteomics, Lipid Metabolism, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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