Yoshimura, Akihiko

SOCS proteins, cytokine signalling and immune regulation

Yoshimura, A., Naka, T., & Kubo, M. (2007) · Nature Reviews Immunology

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 1,580

A new protein containing an SH2 domain that inhibits JAK kinases

Endo, T. A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Tanimura, S., Ohtsubo, M., Misawa, H., et al. (1997) · Nature

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 1,408

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

Stumhofer, J. S., Laurence, A., Wilson, E. H., Huang, E., Tato, C. M., Johnson, L. M., Villarino, A. V., Huang, Q., Yoshimura, A., Sehy, D., et al. (2006) · Nature Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 955

NR4A transcription factors limit CAR T cell function in solid tumours

Chen, J., López-Moyado, I. F., Seo, H., Lio, C.-W. J., Hempleman, L. J., Sekiya, T., Yoshimura, A., Scott-Browne, J. P., & Rao, A. (2019) · Nature

CAR-T cell therapy researchCancer Immunotherapy and Biomarkers

Cited by 874

Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer

Lesina, M., Kurkowski, M. U., Ludes, K., Rose-John, S., Treiber, M., Klöppel, G., Yoshimura, A., Reindl, W., Sipos, B., Akira, S., et al. (2011) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchCytokine Signaling Pathways and Interactions

Cited by 862

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

Shichita, T., Sugiyama, Y., Ooboshi, H., Sugimori, H., Nakagawa, R., Takada, I., Iwaki, T., Okada, Y., Iida, M., Cua, D. J., et al. (2009) · Nature Medicine

Neuroinflammation and Neurodegeneration MechanismsAcute Ischemic Stroke Management

Cited by 842

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

Ito, M., Komai, K., Mise-Omata, S., Iizuka-Koga, M., Noguchi, Y., Kondo, T., Sakai, R., Matsuo, K., Nakayama, T., Yoshie, O., et al. (2019) · Nature

Neuroinflammation and Neurodegeneration MechanismsT-cell and B-cell Immunology

Cited by 784

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Hanada, T., Takeda, K., Akira, S., Hoshijima, M., et al. (2003) · Nature Immunology

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 771

The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

Yasukawa, H., Misawa, H., Sakamoto, H., Masuhara, M., Sasaki, A., Wakioka, T., Ohtsuka, S., Imaizumi, T., Matsuda, T., Ihle, J. N., et al. (1999) · The EMBO Journal

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 719

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

Mori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Nature Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 651

A gp130–Src–YAP module links inflammation to epithelial regeneration

Taniguchi, K., Wu, L.-W., Grivennikov, S. I., de Jong, P. R., Lian, I., Yu, F.-X., Wang, K., Ho, S. B., Boland, B. S., Chang, J. T., et al. (2015) · Nature

Cytokine Signaling Pathways and InteractionsHippo pathway signaling and YAP/TAZ

Cited by 633

SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation

Kinjyo, I., Hanada, T., Inagaki-Ohara, K., Mori, H., Aki, D., Ohishi, M., Yoshida, H., Kubo, M., & Yoshimura, A. (2002) · Immunity

Immune Response and InflammationCytokine Signaling Pathways and Interactions

Cited by 630

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P.-S., Taniki, N., et al. (2019) · Nature Microbiology

Liver Diseases and ImmunityGut microbiota and health

Cited by 425

Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain

Sasaki, A., Yasukawa, H., Suzuki, A., Kamizono, S., Syoda, T., Kinjyo, I., Sasaki, M., Johnston, J. A., & Yoshimura, A. (1999) · Genes to Cells

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 398

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

Marine, J.-C., McKay, C., Wang, D., Topham, D. J., Parganas, E., Nakajima, H., Pendeville, H., Yasukawa, H., Sasaki, A., Yoshimura, A., et al. (1999) · Cell

Cytokine Signaling Pathways and InteractionsHematopoietic Stem Cell Transplantation

Cited by 372

IL-1 and TNF -initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis

Mori, T., Miyamoto, T., Yoshida, H., Asakawa, M., Kawasumi, M., Kobayashi, T., Morioka, H., Chiba, K., Toyama, Y., & Yoshimura, A. (2011) · International Immunology

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 328

MDM2 interacts with MDMX through their RING finger domains

Tanimura, S., Ohtsuka, S., Mitsui, K., Shirouzu, K., Yoshimura, A., & Ohtsubo, M. (1999) · FEBS Letters

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 324

Signal transduction of inflammatory cytokines and tumor development

Yoshimura, A. (2006) · Cancer Science

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 314

The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2

Kamizono, S., Hanada, T., Yasukawa, H., Minoguchi, S., Kato, R., Minoguchi, M., Hattori, K., Hatakeyama, S., Yada, M., Morita, S., et al. (2001) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsUbiquitin and proteasome pathways

Cited by 311

Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production

Ogata, H., Chinen, T., Yoshida, T., Kinjyo, I., Takaesu, G., Shiraishi, H., Iida, M., Kobayashi, T., & Yoshimura, A. (2006) · Oncogene

Liver physiology and pathologyCytokine Signaling Pathways and Interactions

Cited by 246

SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130

Lehmann, U., Schmitz, J., Weissenbach, M., Sobota, R. M., Hörtner, M., Friederichs, K., Behrmann, I., Tsiaris, W., Sasaki, A., Schneider-Mergener, J., et al. (2003) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 236

Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation

Yoshida, T., Hanada, T., Tokuhisa, T., Kosai, K.-I., Sata, M., Kohara, M., & Yoshimura, A. (2002) · The Journal of Experimental Medicine

Cytokine Signaling Pathways and InteractionsHepatitis C virus research

Cited by 236

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1

Kinjyo, I., Inoue, H., Hamano, S., Fukuyama, S., Yoshimura, T., Koga, K., Takaki, H., Himeno, K., Takaesu, G., Kobayashi, T., et al. (2006) · The Journal of Experimental Medicine

Cytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology

Cited by 225

Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke

Shichita, T., Ago, T., Kamouchi, M., Kitazono, T., Yoshimura, A., & Ooboshi, H. (2012) · Journal of Neurochemistry

Neuroinflammation and Neurodegeneration MechanismsAcute Ischemic Stroke Management

Cited by 136