Yoshimura, Akihiko

SOCS3 Is a Physiological Negative Regulator for Granulopoiesis and Granulocyte Colony-stimulating Factor Receptor Signaling

Kimura, A., Kinjyo, I., Matsumura, Y., Mori, H., Mashima, R., Harada, M., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsBlood disorders and treatments

Cited by 119

Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor

Yoshimura, A., Zimmers, T., Neumann, D., Longmore, G., Yoshimura, Y., & Lodish, H. F. (1992) · Journal of Biological Chemistry

Erythropoietin and Anemia TreatmentCytokine Signaling Pathways and Interactions

Cited by 112

Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy

Chikuma, S., Kanamori, M., Mise‐Omata, S., & Yoshimura, A. (2017) · Cancer Science

Cytokine Signaling Pathways and InteractionsCancer Immunotherapy and Biomarkers

Cited by 112

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling

FISCHER, P., LEHMANN, U., SOBOTA, R. M., SCHMITZ, J., NIEMAND, C., LINNEMANN, S., HAAN, S., BEHRMANN, I., YOSHIMURA, A., JOHNSTON, J. A., et al. (2004) · Biochemical Journal

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 72

Peptidoglycan and lipopolysaccharide activate PLCγ2, leading to enhanced cytokine production in macrophages and dendritic cells

Aki, D., Minoda, Y., Yoshida, H., Watanabe, S., Yoshida, R., Takaesu, G., Chinen, T., Inaba, T., Hikida, M., Kurosaki, T., et al. (2008) · Genes to Cells

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 68

FLN29 Deficiency Reveals Its Negative Regulatory Role in the Toll-like Receptor (TLR) and Retinoic Acid-inducible Gene I (RIG-I)-like Helicase Signaling Pathway

Sanada, T., Takaesu, G., Mashima, R., Yoshida, R., Kobayashi, T., & Yoshimura, A. (2008) · Journal of Biological Chemistry

Immune Response and Inflammationinterferon and immune responses

Cited by 66

NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment

Srirat, T., Hayakawa, T., Mise-Omata, S., Nakagawara, K., Ando, M., Shichino, S., Ito, M., & Yoshimura, A. (2024) · Cell Reports

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 56

The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK–STAT activation

Iwamoto, T., Senga, T., Naito, Y., Matsuda, S., Miyake, Y., Yoshimura, A., & Hamaguchi, M. (2000) · Oncogene

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 36

Stage-specific roles of clonally expanded CD8+ T cells in regulating amyloid pathology in Alzheimer’s disease models

Ohyagi, M., Ito, M., Iizuka-Koga, M., Mise-Omata, S., & Yoshimura, A. (2025) · Nature Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 24

The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models

Aki, D., Hayakawa, T., Srirat, T., Shichino, S., Ito, M., Saitoh, S.-I., Mise-Omata, S., & Yoshimura, A. (2024) · Journal of Clinical Investigation

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 22

Essential Roles of the Transcription Factor NR4A1 in Regulatory T Cell Differentiation under the Influence of Immunosuppressants

Sekiya, T., Kasahara, H., Takemura, R., Fujita, S., Kato, J., Doki, N., Katayama, Y., Ozawa, Y., Takada, S., Eto, T., et al. (2022) · The Journal of Immunology

T-cell and B-cell ImmunologyNuclear Receptors and Signaling

Cited by 16