Bumcrot, David

RNAi-mediated gene silencing in non-human primates

Zimmermann, T. S., Lee, A. C. H., Akinc, A., Bramlage, B., Bumcrot, D., Fedoruk, M. N., Harborth, J., Heyes, J. A., Jeffs, L. B., John, M., et al. (2006) · Nature

RNA Interference and Gene DeliveryVirus-based gene therapy research

Cited by 1,357

Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10

Maeder, M. L., Stefanidakis, M., Wilson, C. J., Baral, R., Barrera, L. A., Bounoutas, G. S., Bumcrot, D., Chao, H., Ciulla, D. M., DaSilva, J. A., et al. (2019) · Nature Medicine

Retinal Development and DisordersCRISPR and Genetic Engineering

Cited by 707

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe−/− mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia

Schmidt, P. J., Toudjarska, I., Sendamarai, A. K., Racie, T., Milstein, S., Bettencourt, B. R., Hettinger, J., Bumcrot, D., & Fleming, M. D. (2013) · Blood

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 204

Induction of dopaminergic neuron phenotype in the midbrain by sonic hedgehog protein

Wang, M. Z., Jin, P., Bumcrot, D. A., Marigo, V., Mcmahon, A. P., Wang, E. A., Woolf, T., & Pang, K. (1995) · Nature Medicine

Hedgehog Signaling Pathway StudiesDevelopmental Biology and Gene Regulation

Cited by 158