Cited by 158Hedgehog Signaling Pathway StudiesDevelopmental Biology and Gene RegulationPluripotent Stem Cells Research

Induction of dopaminergic neuron phenotype in the midbrain by sonic hedgehog protein

Wang, Monica Z., Jin, Ping, Bumcrot, David A., Marigo, Valaria, Mcmahon, Andrew P., Wang, Elizabeth A., Woolf, Tod, Pang, Kevin·1995·Nature Medicine

Abstract

Loss of substantia nigra dopaminergic neurons, which develop from the ventral region of the midbrain, is associated with Parkinson's disease. During embryogenesis, induction of these and other ventral neurons is influenced by interactions with the induction of mesoderm of the notochord and the floor plate, which lies at the ventral midline of the developing CNS. Sonic hedgehog encodes a secreted peptide, which is expressed in notochord and floor plate cells and can induce appropriate ventral cell types in the basal forebrain and spinal cord. Here we demonstrate that Sonic hedgehog is sufficient to induce dopaminergic and other neuronal phenotypes in chick mesencephalic explants in vitro. We find that Sonic hedgehog is a general ventralizing signal in the CNS, the specific response being determined by the receiving cells. These results suggest that Sonic hedgehog may have utility in the induction of clinically important cell types.

Integrity signals

Registry

Crossref · 10.1038/nm1195-1184

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Wang, M. Z., Jin, P., Bumcrot, D. A., Marigo, V., Mcmahon, A. P., Wang, E. A., Woolf, T., & Pang, K.
Affiliations
Harvard University (US)
Venue
Nature Medicine
Published
1995-11
Volume
1
Issue
11
Pages
1184-1188
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W2010410556
Cited by
158
References
29
Citations by year
2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 3 · 2015: 1 · 2014: 6 · 2013: 3 · 2012: 6
FWCI
2.73
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords
Sonic hedgehog, dopaminergic neurons, substantia nigra, midbrain, Parkinson's disease, neuronal differentiation, ventralization, floor plate, notochord, chick embryo, cell fate specification
MeSH terms
Animals, Base Sequence, Chick Embryo, Dihydroxyphenylalanine, Dopamine, Embryonic Induction, Enzyme Induction, Mesencephalon, Molecular Sequence Data, Neurons, Parkinson Disease, Proteins, Recombinant Proteins, Tyrosine 3-Monooxygenase, Biomarkers, Trans-Activators, Polymerase Chain Reaction, Culture Techniques, Mice, Hedgehog Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review