Sayed, Nazish

An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

Sayed, N., Huang, Y., Nguyen, K., Krejciova-Rajaniemi, Z., Grawe, A. P., Gao, T., Tibshirani, R., Hastie, T., Alpert, A., Cui, L., et al. (2021) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 572

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

Sharma, A., Burridge, P. W., McKeithan, W. L., Serrano, R., Shukla, P., Sayed, N., Churko, J. M., Kitani, T., Wu, H., Holmström, A., et al. (2017) · Science Translational Medicine

Chemotherapy-induced cardiotoxicity and mitigationPluripotent Stem Cells Research

Cited by 404

Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation

Sayed, N., Baskaran, P., Ma, X., van den Akker, F., & Beuve, A. (2007) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsReceptor Mechanisms and Signaling

Cited by 221

Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer

Kitani, T., Ong, S.-G., Lam, C. K., Rhee, J.-W., Zhang, J. Z., Oikonomopoulos, A., Ma, N., Tian, L., Lee, J., Telli, M. L., et al. (2019) · Circulation

Chemotherapy-induced cardiotoxicity and mitigationPluripotent Stem Cells Research

Cited by 200

Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro

Matsa, E., Burridge, P. W., Yu, K.-H., Ahrens, J. H., Termglinchan, V., Wu, H., Liu, C., Shukla, P., Sayed, N., Churko, J. M., et al. (2016) · Cell stem cell

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

Cited by 164

Nitroglycerin-Induced S-nitrosylation and Desensitization of Soluble Guanylyl Cyclase Contribute to Nitrate Tolerance

Sayed, N., Kim, D. D., Fioramonti, X., Iwahashi, T., Durán, W. N., & Beuve, A. (2008) · Circulation Research

Nitric Oxide and Endothelin EffectsReceptor Mechanisms and Signaling

Cited by 115

Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy

Sayed, N., Liu, C., Ameen, M., Himmati, F., Zhang, J. Z., Khanamiri, S., Moonen, J.-R., Wnorowski, A., Cheng, L., Rhee, J.-W., et al. (2020) · Science Translational Medicine

Pluripotent Stem Cells ResearchCardiomyopathy and Myosin Studies

Cited by 111