Cited by 111Pluripotent Stem Cells ResearchCardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias

Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy

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Sayed, Nazish, Liu, Chun, Ameen, Mohamed, Himmati, Farhan, Zhang, Joe Z., Khanamiri, Saereh, Moonen, Jan-Renier, Wnorowski, Alexa +9 more·2020·Science Translational Medicine

Abstract

Patient-specific iPSCs model endothelial dysfunction in lamin A and C–related dilated cardiomyopathy and identify lovastatin as a therapy.

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Authors
Sayed, N., Liu, C., Ameen, M., Himmati, F., Zhang, J. Z., Khanamiri, S., Moonen, J.-R., Wnorowski, A., Cheng, L., Rhee, J.-W., Gaddam, S., Wang, K. C., Sallam, K., Boyd, J. H., Woo, Y. J., Rabinovitch, M., & Wu, J. C.
Affiliations
  • Stanford Medicine (US)
  • Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Corresponding author
  • Sayed, Nazish
  • Liu, Chun
  • Wu, Joseph C.
Venue
Science Translational Medicine
Published
2020-07-29
Volume
12
Issue
554
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W3045708127
Cited by
111
References
64
Citations by year
2026: 17 · 2025: 14 · 2024: 23 · 2023: 24 · 2022: 14 · 2021: 16 · 2020: 3
FWCI
4.62
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (R01 HL130020, R01 HL113006, R01 HL123968, R01 HL141371, R01 HL141851, and R01 HL126527, K01 HL135455)
  • American Heart Association (13SDG17340025, 19CDA34760019)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
LMNA cardiomyopathy, dilated cardiomyopathy, endothelial dysfunction, lovastatin, statins, induced pluripotent stem cell-derived endothelial cells, iPSC-derived cardiomyocytes, KLF2, angiogenesis, nitric oxide, chromatin accessibility, genome editing, reactive hyperemia
MeSH terms
Cardiomyopathy, Dilated, Humans, Lovastatin, Lamin Type A, Endothelial Cells, Induced Pluripotent Stem Cells

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