Donnelly, Christopher J.

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.

Zhang, K., Donnelly, C. J., Haeusler, A. R., Grima, J. C., Machamer, J. B., Steinwald, P., Daley, E. L., Miller, S. J., Cunningham, K. M., Vidensky, S., et al. (2015) · Nature

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

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C9orf72 nucleotide repeat structures initiate molecular cascades of disease

Haeusler, A. R., Donnelly, C. J., Periz, G., Simko, E. A. J., Shaw, P. G., Kim, M.-S., Maragakis, N. J., Troncoso, J. C., Pandey, A., Sattler, R., et al. (2014) · Nature

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 978

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

Donnelly, C. J., Zhang, P.-W., Pham, J. T., Haeusler, A. R., Mistry, N. A., Vidensky, S., Daley, E. L., Poth, E. M., Hoover, B., Fines, D. M., et al. (2013) · Neuron

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 877

An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke

Li, S., Overman, J. J., Katsman, D., Kozlov, S. V., Donnelly, C. J., Twiss, J. L., Giger, R. J., Coppola, G., Geschwind, D. H., & Carmichael, S. T. (2010) · Nature Neuroscience

Nerve injury and regenerationAxon Guidance and Neuronal Signaling

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Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

Anderson, E. N., Morera, A. A., Kour, S., Cherry, J. D., Ramesh, N., Gleixner, A., Schwartz, J. C., Ebmeier, C., Old, W., Donnelly, C. J., et al. (2021) · eLife

Amyotrophic Lateral Sclerosis ResearchTraumatic Brain Injury Research

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Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Copley, K. E., Mauna, J. C., Danielson, H. L., Chen, Q., Ozguney, B., Ngo, M., Xie, L., Smirnov, A., Davis, M., Mayne, L., et al. (2026) · Science

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

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