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Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

Anderson, Eric N, Morera, Andrés A, Kour, Sukhleen, Cherry, Jonathan D, Ramesh, Nandini, Gleixner, Amanda, Schwartz, Jacob C, Ebmeier, Christopher +7 more·2021·eLife
DOI 10.7554/elife.67587PMC PMC8169113
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Abstract

Traumatic brain injury (TBI) is a predisposing factor for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and chronic traumatic encephalopathy (CTE). Although defects in nucleocytoplasmic transport (NCT) is reported ALS and other neurodegenerative diseases, whether defects in NCT occur in TBI remains unknown. We performed proteomic analysis on Drosophila exposed to repeated TBI and identified resultant alterations in several novel molecular pathways. TBI upregulated nuclear pore complex (NPC) and nucleocytoplasmic transport (NCT) proteins as well as alter nucleoporin stability. Traumatic injury disrupted RanGAP1 and NPC protein distribution in flies and a rat model and led to coaggregation of NPC components and TDP-43. In addition, trauma-mediated NCT defects and lethality are rescued by nuclear export inhibitors. Importantly, genetic upregulation of nucleoporins in vivo and in vitro triggered TDP-43 cytoplasmic mislocalization, aggregation, and altered solubility and reduced motor function and lifespan of animals. We also found NUP62 pathology and elevated NUP62 concentrations in postmortem brain tissues of patients with mild or severe CTE as well as co-localization of NUP62 and TDP-43 in CTE. These findings indicate that TBI leads to NCT defects, which potentially mediate the TDP-43 pathology in CTE.

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  • Patients with traumatic brain injuries have been found to have an overexpression of TDP-43, which contributes to the neurocognitive dysfunction seen in these patients.

    “Patients with traumatic brain injuries have been found to have an overexpression of this protein, which contributes to the neurocognitive dysfunction seen in these patients [46,47,48].”

    From Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry (2025) · cites this paper as [47]

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Cited by

Sorted by citations

Authors
Anderson, E. N., Morera, A. A., Kour, S., Cherry, J. D., Ramesh, N., Gleixner, A., Schwartz, J. C., Ebmeier, C., Old, W., Donnelly, C. J., Cheng, J. P., Kline, A. E., Kofler, J., Stein, T. D., & Pandey, U. B.
Affiliations
  • Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center
  • Department of Chemistry and Biochemistry, University of Arizona
  • Department of Pathology and Laboratory Medicine, Boston University School of Medicine
  • Department of Neurobiology, University of Pittsburgh School of Medicine
  • Molecular, Cellular & Developmental Biology, University of Colorado
  • Physical Medicine & Rehabilitation; Safar Center for Resuscitation Research, University of Pittsburgh
  • Department of Pathology, University of Pittsburgh
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2021-06-01
Volume
10
ISSN
2050-084X
DOI
10.7554/elife.67587
PMC
PMC8169113
Cited by
54
References
6
Language
en
Licence
Funders
  • National Institute of Neurological Disorders and Stroke (R21 AG064940, R01 NS081303, R21 NS098379, U54 NS115266, R01 NS084967, R56 NS113810, 1R00 NS082376)
  • Robert Packard Center for ALS Research, Johns Hopkins University

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

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