Jones, Simon A.

IL-6 as a keystone cytokine in health and disease

Hunter, C. A., & Jones, S. A. (2015) · Nature Immunology

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 2,511

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

Jones, S. A., & Jenkins, B. J. (2018) · Nature Reviews Immunology

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 1,102

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

Hurst, S. M., Wilkinson, T. S., McLoughlin, R. M., Jones, S., Horiuchi, S., Yamamoto, N., Rose-John, S., Fuller, G. M., Topley, N., & Jones, S. A. (2001) · Immunity

Cytokine Signaling Pathways and InteractionsChemokine receptors and signaling

Cited by 811

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling

Jenkins, B. J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R. M., Jones, S. A., Topley, N., et al. (2005) · Nature Medicine

Cytokine Signaling Pathways and InteractionsTGF-β signaling in diseases

Cited by 308

Interplay between IFN-γ and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

McLoughlin, R. M., Witowski, J., Robson, R. L., Wilkinson, T. S., Hurst, S. M., Williams, A. S., Williams, J. D., Rose-John, S., Jones, S. A., & Topley, N. (2003) · Journal of Clinical Investigation

Cytokine Signaling Pathways and InteractionsChemokine receptors and signaling

Cited by 281

On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier

Dutzan, N., Abusleme, L., Bridgeman, H., Greenwell-Wild, T., Zangerle-Murray, T., Fife, M. E., Bouladoux, N., Linley, H., Brenchley, L., Wemyss, K., et al. (2017) · Immunity

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 252

Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis

Nowell, M. A., Williams, A. S., Carty, S. A., Scheller, J., Hayes, A. J., Jones, G. W., Richards, P. J., Slinn, S., Ernst, M., Jenkins, B. J., et al. (2009) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 215

Implications of the serine protease HtrA1 in amyloid precursor protein processing

Grau, S., Baldi, A., Bussani, R., Tian, X., Stefanescu, R., Przybylski, M., Richards, P., Jones, S. A., Shridhar, V., Clausen, T., et al. (2005) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsProtease and Inhibitor Mechanisms

Cited by 215

Loss of CD4+ T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 Trans Signaling in the Local Maintenance of Th17 Cells

Jones, G. W., McLoughlin, R. M., Hammond, V. J., Parker, C. R., Williams, J. D., Malhotra, R., Scheller, J., Williams, A. S., Rose-John, S., Topley, N., et al. (2010) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology

Cited by 189

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases

Garbers, C., Monhasery, N., Aparicio-Siegmund, S., Lokau, J., Baran, P., Nowell, M. A., Jones, S. A., Rose-John, S., & Scheller, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Cytokine Signaling Pathways and InteractionsProtease and Inhibitor Mechanisms

Cited by 155

T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity

Harbour, S. N., DiToro, D. F., Witte, S. J., Zindl, C. L., Gao, M., Schoeb, T. R., Jones, G. W., Jones, S. A., Hatton, R. D., & Weaver, C. T. (2020) · Science Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 151