Karch, Jason

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

Khalil, H., Kanisicak, O., Prasad, V., Correll, R. N., Fu, X., Schips, T., Vagnozzi, R. J., Liu, R., Huynh, T., Lee, S.-J., et al. (2017) · Journal of Clinical Investigation

Cardiac Fibrosis and RemodelingTGF-β signaling in diseases

Cited by 905

Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice

Elrod, J. W., Wong, R., Mishra, S., Vagnozzi, R. J., Sakthievel, B., Goonasekera, S. A., Karch, J., Gabel, S., Farber, J., Force, T., et al. (2010) · Journal of Clinical Investigation

Mitochondrial Function and PathologySignaling Pathways in Disease

Cited by 384

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

Karch, J., Kwong, J. Q., Burr, A. R., Sargent, M. A., Elrod, J. W., Peixoto, P. M., Martinez-Caballero, S., Osinska, H., Cheng, E. H.-Y., Robbins, J., et al. (2013) · eLife

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 290

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

Karch, J., Bround, M. J., Khalil, H., Sargent, M. A., Latchman, N., Terada, N., Peixoto, P. M., & Molkentin, J. D. (2019) · Science Advances

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 250

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

Kwong, J. Q., Davis, J., Baines, C. P., Sargent, M. A., Karch, J., Wang, X., Huang, T., & Molkentin, J. D. (2014) · Cell Death & Differentiation

Mitochondrial Function and PathologyCardiac Ischemia and Reperfusion

Cited by 174

Autophagic cell death is dependent on lysosomal membrane permeability through bax and bak

Karch, J., Schips, T. G., Maliken, B. D., Brody, M. J., Sargent, M. A., Kanisicak, O., & Molkentin, J. D. (2017) · eLife

Autophagy in Disease and TherapyCell death mechanisms and regulation

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