Nussenzweig, André

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

Ray Chaudhuri, A., & Nussenzweig, A. (2017) · Nature Reviews Molecular Cell Biology

PARP inhibition in cancer therapyDNA Repair Mechanisms

Cited by 1,786

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 1,671

Endogenous DNA damage as a source of genomic instability in cancer

Tubbs, A., & Nussenzweig, A. (2017) · Cell

DNA Repair MechanismsCancer Genomics and Diagnostics

Cited by 1,452

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Celeste, A., Fernandez-Capetillo, O., Kruhlak, M. J., Pilch, D. R., Staudt, D. W., Lee, A., Bonner, R. F., Bonner, W. M., & Nussenzweig, A. (2003) · Nature Cell Biology

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 989

Genome Organization Drives Chromosome Fragility

Canela, A., Maman, Y., Jung, S., Wong, N., Callen, E., Day, A., Kieffer-Kwon, K.-R., Pekowska, A., Zhang, H., Rao, S. S. P., et al. (2017) · Cell

Genomics and Chromatin DynamicsDNA Repair Mechanisms

Cited by 383

The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

Kruhlak, M., Crouch, E. E., Orlov, M., Montaño, C., Gorski, S. A., Nussenzweig, A., Misteli, T., Phair, R. D., & Casellas, R. (2007) · Nature

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 305

DNA Breaks and End Resection Measured Genome-wide by End Sequencing

Canela, A., Sridharan, S., Sciascia, N., Tubbs, A., Meltzer, P., Sleckman, B. P., & Nussenzweig, A. (2016) · Molecular Cell

DNA Repair MechanismsCRISPR and Genetic Engineering

Cited by 284

BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair

Bunting, S. F., Callén, E., Kozak, M. L., Kim, J. M., Wong, N., López-Contreras, A. J., Ludwig, T., Baer, R., Faryabi, R. B., Malhowski, A., et al. (2012) · Molecular Cell

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 252

Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1

Bothmer, A., Robbiani, D. F., Di Virgilio, M., Bunting, S. F., Klein, I. A., Feldhahn, N., Barlow, J., Chen, H.-T., Bosque, D., Callen, E., et al. (2011) · Molecular Cell

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 244

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

Difilippantonio, S., Celeste, A., Fernandez-Capetillo, O., Chen, H.-T., Martin, B. R. S., Laethem, F. V., Yang, Y.-P., Petukhova, G. V., Eckhaus, M., Feigenbaum, L., et al. (2005) · Nature Cell Biology

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 227

Neuronal enhancers are hotspots for DNA single-strand break repair

Wu, W., Kargbo-Hill, S. E., Nathan, W. J., Paiano, J., Callen, E., Wang, D., Shinoda, K., van Wietmarschen, N., Colón-Mercado, J. M., Zong, D., et al. (2021) · Nature

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 223

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

Sekiguchi, J., Ferguson, D. O., Chen, H. T., Yang, E. M., Earle, J., Frank, K., Whitlow, S., Gu, Y., Xu, Y., Nussenzweig, A., et al. (2001) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 156

Active DNA demethylation promotes cell fate specification and the DNA damage response

Wang, D., Wu, W., Callen, E., Pavani, R., Zolnerowich, N., Kodali, S., Zong, D., Wong, N., Noriega, S., Nathan, W. J., et al. (2022) · Science

DNA Repair MechanismsEpigenetics and DNA Methylation

Cited by 113

RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1

Setiaputra, D., Escribano-Díaz, C., Reinert, J. K., Sadana, P., Zong, D., Callen, E., Sifri, C., Seebacher, J., Nussenzweig, A., Thomä, N. H., et al. (2022) · Molecular Cell

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 43

Paradoxical decrease in mutant frequencies and chromosomal rearrangements in a transgenic lacZ reporter gene in Ku80 null mice deficient in DNA double strand break repair

Rockwood, L. D., Nussenzweig, A., & Janz, S. (2003) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

DNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Cited by 15