Wang, Weiru

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

Tsai, J., Lee, J. T., Wang, W., Zhang, J., Cho, H., Mamo, S., Bremer, R., Gillette, S., Kong, J., Haass, N. K., et al. (2008) · Proceedings of the National Academy of Sciences

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

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Recurrent R-spondin fusions in colon cancer

Seshagiri, S., Stawiski, E. W., Durinck, S., Modrusan, Z., Storm, E. E., Conboy, C. B., Chaudhuri, S., Guan, Y., Janakiraman, V., Jaiswal, B. S., et al. (2012) · Nature

Cancer Genomics and DiagnosticsGenetic factors in colorectal cancer

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Maurer, T., Garrenton, L. S., Oh, A., Pitts, K., Anderson, D. J., Skelton, N. J., Fauber, B. P., Pan, B., Malek, S., Stokoe, D., et al. (2012) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 618

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo

Atwal, J. K., Chen, Y., Chiu, C., Mortensen, D. L., Meilandt, W. J., Liu, Y., Heise, C. E., Hoyte, K., Luk, W., Lu, Y., et al. (2011) · Science Translational Medicine

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Cited by 274

Targeting Protein-Protein Interaction by Small Molecules

Jin, L., Wang, W., & Fang, G. (2014) · Annual Review of Pharmacology and Toxicology

Chemical Synthesis and AnalysisProtein Degradation and Inhibitors

Cited by 195

Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

Ultsch, M., Li, B., Maurer, T., Mathieu, M., Adolfsson, O., Muhs, A., Pfeifer, A., Pihlgren, M., Bainbridge, T. W., Reichelt, M., et al. (2016) · Scientific Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 124

Disruption of IRE1α through its kinase domain attenuates multiple myeloma

Harnoss, J. M., Le Thomas, A., Shemorry, A., Marsters, S. A., Lawrence, D. A., Lu, M., Chen, Y.-C. A., Qing, J., Totpal, K., Kan, D., et al. (2019) · Proceedings of the National Academy of Sciences

Endoplasmic Reticulum Stress and DiseaseMultiple Myeloma Research and Treatments

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A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRAS G12C inhibitors

Feng, S., Callow, M. G., Fortin, J.-P., Khan, Z., Bray, D., Costa, M., Shi, Z., Wang, W., & Evangelista, M. (2022) · Proceedings of the National Academy of Sciences

Lung Cancer Treatments and MutationsProtein Kinase Regulation and GTPase Signaling

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