Roe, S. Mark

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.

Roe, S. M., Prodromou, C., O'Brien, R., Ladbury, J. E., Piper, P. W., & Pearl, L. H. (1999) · Journal of Medicinal Chemistry

Heat shock proteins researchProtein Structure and Dynamics

Cited by 1,004

Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex

Ali, M. M. U., Roe, S. M., Vaughan, C. K., Meyer, P., Panaretou, B., Piper, P. W., Prodromou, C., & Pearl, L. H. (2006) · Nature

Heat shock proteins researchProtein Structure and Dynamics

Cited by 962

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

Panaretou, B., Prodromou, C., Roe, S. M., O'Brien, R., Ladbury, J. E., Piper, P. W., & Pearl, L. H. (1998) · The EMBO Journal

Heat shock proteins researchProtein Structure and Dynamics

Cited by 735

The ATPase cycle of Hsp90 drives a molecular ‘clamp’ via transient dimerization of the N‐terminal domains

Prodromou, C., Panaretou, B., Chohan, S., Siligardi, G., O'Brien, R., Ladbury, J. E., Roe, S. M., Piper, P. W., & Pearl, L. H. (2000) · The EMBO Journal

Heat shock proteins researchProtein Structure and Dynamics

Cited by 492

Structural and Functional Analysis of the Middle Segment of Hsp90: Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions

Meyer, P., Prodromou, C., Hu, B., Vaughan, C., Roe, S. M., Panaretou, B., Piper, P. W., & Pearl, L. H. (2003) · Molecular Cell

Heat shock proteins researchProtein Structure and Dynamics

Cited by 491

Structural basis for recruitment of glycogen synthase kinase 3β to the axin—APC scaffold complex

Dajani, R., Fraser, E., Roe, S. M., Yeo, M., Good, V. M., Thompson, V., Dale, T. C., & Pearl, L. H. (2003) · The EMBO Journal

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 315

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

Prodromou, C., Roe, S. M., Piper, P. W., & Pearl, L. H. (1997) · Nature Structural Biology

Heat shock proteins researchProtein Structure and Dynamics

Cited by 239

Activation of Rho GTPases by DOCK Exchange Factors Is Mediated by a Nucleotide Sensor

Yang, J., Zhang, Z., Roe, S. M., Marshall, C. J., & Barford, D. (2009) · Science

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 123

Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2

Bunney, T. D., Opaleye, O., Roe, S. M., Vatter, P., Baxendale, R. W., Walliser, C., Everett, K. L., Josephs, M. B., Christow, C., Rodrigues-Lima, F., et al. (2009) · Molecular Cell

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 72

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

Chen, X., Ali, Y. I., Fisher, C. E., Arribas-Bosacoma, R., Rajasekaran, M. B., Williams, G., Walker, S., Booth, J. R., Hudson, J. J., Roe, S. M., et al. (2021) · eLife

DNA Repair MechanismsEnzyme Structure and Function

Cited by 34