Crawford, Lorin

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

Raghavan, S., Winter, P. S., Navia, A. W., Williams, H. L., DenAdel, A., Lowder, K. E., Galvez-Reyes, J., Kalekar, R. L., Mulugeta, N., Kapner, K. S., et al. (2021) · Cell

Pancreatic and Hepatic Oncology ResearchSingle-cell and spatial transcriptomics

Cited by 592

Zero-shot evaluation reveals limitations of single-cell foundation models

Kedzierska, K. Z., Crawford, L., Amini, A. P., & Lu, A. X. (2025) · Genome Biology

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 109

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution

Anderson, G. R., Winter, P. S., Lin, K. H., Nussbaum, D. P., Cakir, M., Stein, E. M., Soderquist, R. S., Crawford, L., Leeds, J. C., Newcomb, R., et al. (2017) · Cell Reports

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 80

Assessing the limits of zero-shot foundation models in single-cell biology

Kedzierska, K. Z., Crawford, L., Amini, A. P., & Lu, A. X. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 61

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation

Anderson, G. R., Wardell, S. E., Cakir, M., Crawford, L., Leeds, J. C., Nussbaum, D. P., Shankar, P. S., Soderquist, R. S., Stein, E. M., Tingley, J. P., et al. (2016) · Science Translational Medicine

PI3K/AKT/mTOR signaling in cancerAdvanced Breast Cancer Therapies

Cited by 53

The Landscape of Glycogen Synthase Kinase-3 Beta Genomic Alterations in Cancer

Borden, B. A., Baca, Y., Xiu, J., Tavora, F., Winer, I., Weinberg, B. A., Vanderwalde, A. M., Darabi, S., Korn, W. M., Mazar, A. P., et al. (2021) · Molecular Cancer Therapeutics

Cancer Genomics and DiagnosticsCancer Immunotherapy and Biomarkers

Cited by 15