Brafman, David A.

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

Zhao, J., Fu, Y., Yamazaki, Y., Ren, Y., Davis, M. D., Liu, C.-C., Lu, W., Wang, X., Chen, K., Cherukuri, Y., et al. (2020) · Nature Communications

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 374

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions

Brafman, D. A., Phung, C., Kumar, N., & Willert, K. (2013) · Cell Death & Differentiation

Pluripotent Stem Cells ResearchCell Adhesion Molecules Research

Cited by 126

The multifaceted role of WNT signaling in Alzheimer’s disease onset and age-related progression.

Kostes, W. W., & Brafman, D. A. (2023) · Cells

Alzheimer's disease research and treatmentsWnt/β-catenin signaling in development and cancer

Cited by 43

APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer’s disease

Brookhouser, N., Raman, S., Frisch, C., Srinivasan, G., & Brafman, D. A. (2021) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 33

PINE-TREE enables highly efficient genetic modification of human cell lines.

Frisch, C., Kostes, W. W., Galyon, B., Whitman, B., Tekel, S. J., Standage-Beier, K., Srinivasan, G., Wang, X., & Brafman, D. A. (2023) · Molecular Therapy - Nucleic Acids

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 9

Isogenic human stem cell models reveal mutation-dependent protective mechanisms of APOE3 Christchurch

Frisch, C., Baker, L., Srinivasan, G., Mintah, A. E., Leyasi, S., Pedroza, M., Galyon, B., & Brafman, D. A. (2026) · Frontiers in Aging Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 0