Pfeffer, Suzanne R

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Dhekne, H. S., Yanatori, I., Gomez, R. C., Tonelli, F., Diez, F., Schüle, B., Steger, M., Alessi, D. R., & Pfeffer, S. R. (2018) · eLife

Parkinson's Disease Mechanisms and TreatmentsGenetic and Kidney Cyst Diseases

Cited by 240

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Khan, S. S., Sobu, Y., Dhekne, H. S., Tonelli, F., Berndsen, K., Alessi, D. R., & Pfeffer, S. R. (2021) · eLife

Parkinson's Disease Mechanisms and TreatmentsGenetic and Kidney Cyst Diseases

Cited by 93

Multiple Rab GTPase Binding Sites in GCC185 Suggest a Model for Vesicle Tethering at the Trans -Golgi

Hayes, G. L., Brown, F. C., Haas, A. K., Nottingham, R. M., Barr, F. A., & Pfeffer, S. R. (2009) · Molecular Biology of the Cell

Cellular transport and secretionFungal and yeast genetics research

Cited by 92

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

Dhekne, H. S., Tonelli, F., Yeshaw, W. M., Chiang, C. Y., Limouse, C., Jaimon, E., Purlyte, E., Alessi, D. R., & Pfeffer, S. R. (2023) · eLife

Parkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

Cited by 76

The Rab6-regulated KIF1C kinesin motor domain contributes to Golgi organization

Lee, P. L., Ohlson, M. B., & Pfeffer, S. R. (2015) · eLife

Microtubule and mitosis dynamicsCellular transport and secretion

Cited by 65

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

Vides, E. G., Adhikari, A., Chiang, C. Y., Lis, P., Purlyte, E., Limouse, C., Shumate, J. L., Spínola-Lasso, E., Dhekne, H. S., Alessi, D. R., et al. (2022) · eLife

Parkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

Cited by 63

A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation

Vides, E. G., Adhikari, A., Chiang, C. Y., Lis, P., Purlyte, E., Limouse, C., Shumate, J. L., Spínola-Lasso, E., Dhekne, H. S., Alessi, D. R., et al. (2022) · eLife

Parkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

Cited by 63

Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease

Khan, S. S., Jaimon, E., Lin, Y.-E., Nikoloff, J., Tonelli, F., Alessi, D. R., & Pfeffer, S. R. (2024) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsGenetic and Kidney Cyst Diseases

Cited by 61

Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B

Pal, P., Taylor, M., Lam, P. Y., Tonelli, F., Hecht, C. A., Lis, P., Nirujogi, R. S., Phung, T. K., Yeshaw, W. M., Jaimon, E., et al. (2023) · Science Advances

Parkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

Cited by 36

Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal parvalbumin interneurons

Lin, Y.-E., Jaimon, E., Tonelli, F., & Pfeffer, S. R. (2025) · Life Science Alliance

Parkinson's Disease Mechanisms and TreatmentsGenetic and Kidney Cyst Diseases

Cited by 16

End-product inhibition of the LRRK2-counteracting PPM1H phosphatase

Adhikari, A., Tripathi, A., Chiang, C. Y., Sherpa, P., & Pfeffer, S. R. (2025) · Journal of Biological Chemistry

Protein Tyrosine PhosphatasesParkinson's Disease Mechanisms and Treatments

Cited by 3