Dokholyan, Nikolay V.

Allostery in Its Many Disguises: From Theory to Applications

Wodak, S. J., Paci, E., Dokholyan, N. V., Berezovsky, I. N., Horovitz, A., Li, J., Hilser, V. J., Bahar, I., Karanicolas, J., Stock, G., et al. (2019) · Structure

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 404

Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis

Cholon, D. M., Quinney, N. L., Fulcher, M. L., Esther, C. R., Das, J., Dokholyan, N. V., Randell, S. H., Boucher, R. C., & Gentzsch, M. (2014) · Science Translational Medicine

Cystic Fibrosis Research AdvancesInhalation and Respiratory Drug Delivery

Cited by 320

Controlling Allosteric Networks in Proteins

Dokholyan, N. V. (2016) · Chemical Reviews

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 260

Mapping allosteric communications within individual proteins

Wang, J., Jain, A., McDonald, L. R., Gambogi, C., Lee, A. L., & Dokholyan, N. V. (2020) · Nature Communications

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 201

The Complex Molecular Biology of Amyotrophic Lateral Sclerosis (ALS)

Redler, R. L., & Dokholyan, N. V. (2012) · Progress in Molecular Biology and Translational Science

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 172

Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis

Proctor, E. A., Fee, L., Tao, Y., Redler, R. L., Fay, J. M., Zhang, Y., Lv, Z., Mercer, I. P., Deshmukh, M., Lyubchenko, Y. L., et al. (2016) · Proceedings of the National Academy of Sciences

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 131

AlphaFold illuminates half of the dark human proteins

Binder, J. L., Berendzen, J., Stevens, A. O., He, Y., Wang, J., Dokholyan, N. V., & Oprea, T. I. (2022) · Current Opinion in Structural Biology

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 81

Applications of Discrete Molecular Dynamics in biology and medicine

Proctor, E. A., & Dokholyan, N. V. (2016) · Current Opinion in Structural Biology

Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions

Cited by 76

Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator

Proctor, E. A., Kota, P., Aleksandrov, A. A., He, L., Riordan, J. R., & Dokholyan, N. V. (2015) · Chemical Science

Cystic Fibrosis Research AdvancesProtein Structure and Dynamics

Cited by 61

NeuralDock: Rapid and Conformation-Agnostic Docking of Small Molecules

Sha, C. M., Wang, J., & Dokholyan, N. V. (2022) · Frontiers in Molecular Biosciences

Computational Drug Discovery MethodsProtein Degradation and Inhibitors

Cited by 9

Molecular Mechanisms of the R61T Mutation in Apolipoprotein E4: A Dynamic Rescue

Williams, B., Convertino, M., Das, J., & Dokholyan, N. V. (2017) · Biophysical Journal

Alzheimer's disease research and treatmentsProtein Structure and Dynamics

Cited by 5