Okada, Ryo

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

Takahashi, A., Okada, R., Nagao, K., Kawamata, Y., Hanyu, A., Yoshimoto, S., Takasugi, M., Watanabe, S., Kanemaki, M. T., Obuse, C., et al. (2017) · Nature Communications

Extracellular vesicles in diseaseCellular transport and secretion

Cited by 761

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

Takasugi, M., Okada, R., Takahashi, A., Virya Chen, D., Watanabe, S., & Hara, E. (2017) · Nature Communications

Extracellular vesicles in diseaseTelomeres, Telomerase, and Senescence

Cited by 410

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Takahashi, A., Loo, T. M., Okada, R., Kamachi, F., Watanabe, Y., Wakita, M., Watanabe, S., Kawamoto, S., Miyata, K., Barber, G. N., et al. (2018) · Nature Communications

Telomeres, Telomerase, and Senescenceinterferon and immune responses

Cited by 350

Generation of human adult hepatocyte organoids with metabolic functions

Igarashi, R., Oda, M., Okada, R., Yano, T., Takahashi, S., Pastuhov, S., Matano, M., Masuda, N., Togasaki, K., Ohta, Y., et al. (2025) · Nature

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 85

Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer

Miyata, K., Imai, Y., Hori, S., Nishio, M., Loo, T. M., Okada, R., Yang, L., Nakadai, T., Maruyama, R., Fujii, R., et al. (2021) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 74

RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

Sugawara, S., Okada, R., Loo, T. M., Tanaka, H., Miyata, K., Chiba, M., Kawasaki, H., Katoh, K., Kaji, S., Maezawa, Y., et al. (2022) · Communications Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 23

Identification of a novel mycovirus belonging to the “flexivirus”-related family with icosahedral virion

Wu, C.-F., Okada, R., Neri, U., Chang, Y.-C., Takashi, O., Kitaura, K., Komatsu, K., & Moriyama, H. (2024) · Virus Evolution

Plant and Fungal Interactions ResearchPlant Virus Research Studies

Cited by 4