Alt, Frederick W.

SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease

Shin, J., He, M., Liu, Y., Paredes, S., Villanova, L., Brown, K., Qiu, X., Nabavi, N., Mohrin, M., Wojnoonski, K., et al. (2013) · Cell Reports

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Microbial colonization influences early B-lineage development in the gut lamina propria

Wesemann, D. R., Portuguese, A. J., Meyers, R. M., Gallagher, M. P., Cluff-Jones, K., Magee, J. M., Panchakshari, R. A., Rodig, S. J., Kepler, T. B., & Alt, F. W. (2013) · Nature

T-cell and B-cell ImmunologyGut microbiota and health

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Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

Van Gool, F., Gallí, M., Gueydan, C., Kruys, V., Prevot, P.-P., Bedalov, A., Mostoslavsky, R., Alt, F. W., De Smedt, T., & Leo, O. (2009) · Nature Medicine

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

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H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations

Franco, S., Gostissa, M., Zha, S., Lombard, D. B., Murphy, M. M., Zarrin, A. A., Yan, C., Tepsuporn, S., Morales, J. C., Adams, M. M., et al. (2006) · Molecular Cell

DNA Repair MechanismsGenomics and Chromatin Dynamics

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Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells

Wei, P.-C., Chang, A. N., Kao, J., Du, Z., Meyers, R. M., Alt, F. W., & Schwer, B. (2016) · Cell

DNA Repair MechanismsGenomic variations and chromosomal abnormalities

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Calorie restriction alters mitochondrial protein acetylation

Schwer, B., Eckersdorff, M., Li, Y., Silva, J. C., Fermin, D., Kurtev, M. V., Giallourakis, C., Comb, M. J., Alt, F. W., & Lombard, D. B. (2009) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

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WAVE2 deficiency reveals distinct roles in embryogenesis and Rac‐mediated actin‐based motility

Yan, C., Martinez‐Quiles, N., Eden, S., Shibata, T., Takeshima, F., Shinkura, R., Fujiwara, Y., Bronson, R., Snapper, S. B., Kirschner, M. W., et al. (2003) · The EMBO Journal

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

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Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

Sekiguchi, J., Ferguson, D. O., Chen, H. T., Yang, E. M., Earle, J., Frank, K., Whitlow, S., Gu, Y., Xu, Y., Nussenzweig, A., et al. (2001) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsEffects of Radiation Exposure

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Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells

Compagno, M., Wang, Q., Pighi, C., Cheong, T.-C., Meng, F.-L., Poggio, T., Yeap, L.-S., Karaca, E., Blasco, R. B., Langellotto, F., et al. (2017) · Nature

Chronic Lymphocytic Leukemia ResearchLymphoma Diagnosis and Treatment

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Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching

Dong, J., Panchakshari, R. A., Zhang, T., Zhang, Y., Hu, J., Volpi, S. A., Meyers, R. M., Ho, Y.-J., Du, Z., Robbiani, D. F., et al. (2015) · Nature

DNA Repair MechanismsT-cell and B-cell Immunology

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DNA double-strand breaks as drivers of neural genomic change, function, and disease

Alt, F. W., & Schwer, B. (2018) · DNA Repair

DNA Repair MechanismsNeurogenesis and neuroplasticity mechanisms

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Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability

Wang, M., Wei, P.-C., Lim, C. K., Gallina, I. S., Marshall, S., Marchetto, M. C., Alt, F. W., & Gage, F. H. (2020) · Cell Stem Cell

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

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Structural principles of B cell antigen receptor assembly

Dong, Y., Pi, X., Bartels-Burgahn, F., Saltukoglu, D., Liang, Z., Yang, J., Alt, F. W., Reth, M., & Wu, H. (2022) · Nature

T-cell and B-cell ImmunologyReceptor Mechanisms and Signaling

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