DNA double-strand breaks as drivers of neural genomic change, function, and disease

Non-homologous DNA end joining and alternative pathways to double-strand break repair

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Topologically associating domains are stable units of replication-timing regulation

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Subgroup-specific structural variation across 1,000 medulloblastoma genomes

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Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

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A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription

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Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits

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Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

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Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

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Recombination centres and the orchestration of V(D)J recombination

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Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

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Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

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Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV

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Somatic mutation, genomic variation, and neurological disease

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Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

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Mosaic Copy Number Variation in Human Neurons

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Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations

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The integrated landscape of driver genomic alterations in glioblastoma

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Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function

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DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway

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Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

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Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System

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Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles

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Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

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The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

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Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

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Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

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Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations

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Clarifying the mechanics of DNA strand exchange in meiotic recombination

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The Exon Theory of GenesPreprint

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Genome Organization Drives Chromosome Fragility

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Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes

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Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing

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DNA double strand break repair and chromosomal translocation: Lessons from animal models

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Transcription-dependent dynamic supercoiling is a short-range genomic force

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Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells

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Directed evolution of proteins by exon shuffling

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Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks

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Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

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Detecting DNA double-stranded breaks in mammalian genomes by linear amplification–mediated high-throughput genome-wide translocation sequencing

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Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability

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Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders

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Common fragile sites, extremely large genes, neural development and cancer

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Transcriptional elongation requires DNA break-induced signalling

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DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

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Large transcription units unify copy number variants and common fragile sites arising under replication stressPreprint

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Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes

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Genome integrity and disease prevention in the nervous systemPreprint

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XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice

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Antibody Class Switching Mediated by Yeast Endonuclease-Generated DNA Breaks

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Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells

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DNA Break Mapping Reveals Topoisomerase II Activity Genome-Wide

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Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development

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Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes

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IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances

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Maintenance of Genome Stability

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Genome Editing in Neurosciences

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Mechanisms That Can Promote Peripheral B-cell Lymphoma in ATM-Deficient Mice

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Breaks in the brain

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Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer

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On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability

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Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease

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Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements

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DNA Double-Strand Break Accumulation in Alzheimer’s Disease: Evidence from Experimental Models and Postmortem Human Brains

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THE EFFECT OF Aβ ON PROLIFERATION AND DIFFERENTIATION OF NEURAL STEM CELLS

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