Biggin, Philip C.

Accurate calculation of the absolute free energy of binding for drug molecules

Aldeghi, M., Heifetz, A., Bodkin, M. J., Knapp, S., & Biggin, P. C. (2016) · Chemical Science

Computational Drug Discovery MethodsProtein Degradation and Inhibitors

Cited by 347

Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites.

Laverty, D., Thomas, P., Field, M., Andersen, O. J., Gold, M. G., Biggin, P. C., Gielen, M., & Smart, T. G. (2017) · Nature Structural & Molecular Biology

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cited by 179

Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations

Aldeghi, M., Heifetz, A., Bodkin, M. J., Knapp, S., & Biggin, P. C. (2017) · Journal of the American Chemical Society

Computational Drug Discovery MethodsProtein Degradation and Inhibitors

Cited by 177

Biomolecular simulations: from dynamics and mechanisms to computational assays of biological activity

Huggins, D. J., Biggin, P. C., Dämgen, M. A., Essex, J. W., Harris, S. A., Henchman, R. H., Khalid, S., Kuzmanic, A., Laughton, C. A., Michel, J., et al. (2019) · WIREs Computational Molecular Science

Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions

Cited by 169

The mechanism of mammalian proton-coupled peptide transporters

Lichtinger, S. M., Parker, J. L., Newstead, S., & Biggin, P. C. (2024) · eLife

Drug Transport and Resistance MechanismsProtein Structure and Dynamics

Cited by 12

Exploring the Influence of Pore Shape on Conductance and Permeation

Seiferth, D., & Biggin, P. C. (2024) · Biophysical Journal

Nanopore and Nanochannel Transport StudiesIon channel regulation and function

Cited by 9

Exploring the influence of pore shape on conductance and permeation

Seiferth, D., & Biggin, P. C. (2024) · Biophysical Journal

Nanopore and Nanochannel Transport StudiesIon channel regulation and function

Cited by 9

The mechanism of mammalian proton-coupled peptide transporters

Lichtinger, S. M., Parker, J. L., Newstead, S., & Biggin, P. C. (2024) · eLife

Drug Transport and Resistance MechanismsProtein Structure and Dynamics

Cited by 4