Filippakopoulos, Panagis

Selective inhibition of BET bromodomains

Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W. B., Fedorov, O., Morse, E. M., Keates, T., Hickman, T. T., Felletar, I., et al. (2010) · Nature

Protein Degradation and InhibitorsChromatin Remodeling and Cancer

Cited by 4,262

BET inhibition disrupts transcription but retains enhancer-promoter contact

Crump, N. T., Ballabio, E., Godfrey, L., Thorne, R., Repapi, E., Kerry, J., Tapia, M., Hua, P., Lagerholm, C., Filippakopoulos, P., et al. (2021) · Nature Communications

Genomics and Chromatin DynamicsProtein Degradation and Inhibitors

Cited by 123

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

Segatto, M., Fittipaldi, R., Pin, F., Sartori, R., Dae Ko, K., Zare, H., Fenizia, C., Zanchettin, G., Pierobon, E. S., Hatakeyama, S., et al. (2017) · Nature Communications

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 101

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase

Chen, Z., Picaud, S., Filippakopoulos, P., D'Angiolella, V., & Bullock, A. N. (2019) · Structure

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 37