Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
Open accessAbstract
Cancer cachexia is a devastating metabolic syndrome characterized by systemic inflammation and massive muscle and adipose tissue wasting. Although it is responsible for approximately one-third of cancer deaths, no effective therapies are available and the underlying mechanisms have not been fully elucidated. We previously identified the bromodomain and extra-terminal domain (BET) protein BRD4 as an epigenetic regulator of muscle mass. Here we show that the pan-BET inhibitor (+)-JQ1 protects tumor-bearing mice from body weight loss and muscle and adipose tissue wasting. Remarkably, in C26-tumor-bearing mice (+)-JQ1 administration dramatically prolongs survival, without directly affecting tumor growth. By ChIP-seq and ChIP analyses, we unveil that BET proteins directly promote the muscle atrophy program during cachexia. In addition, BET proteins are required to coordinate an IL6-dependent AMPK nuclear signaling pathway converging on FoxO3 transcription factor. Overall, these findings indicate that BET proteins may represent a promising therapeutic target in the management of cancer cachexia.
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BRD4 is an epigenetic regulator of muscle mass.
“The bromodomain and extra terminal domain (BET) protein BRD4 has been recently shown to be an epigenetic regulator of muscle mass80.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [80]
BET proteins promote an IL6-AMPK-FoxO3 response to enhance protein breakdown.
“Mechanistically, BET proteins promote an IL6-AMPK-FoxO3 response to enhance protein breakdown.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [80]
Overactivation of AMPK has been linked to cachexia.
“In fact, the overactivation of AMPK has been linked to cachexia80.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [80]
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- Authors
- Segatto, M., Fittipaldi, R., Pin, F., Sartori, R., Dae Ko, K., Zare, H., Fenizia, C., Zanchettin, G., Pierobon, E. S., Hatakeyama, S., Sperti, C., Merigliano, S., Sandri, M., Filippakopoulos, P., Costelli, P., Sartorelli, V., & Caretti, G.
- Affiliations
- University of Milan (IT)
- University of Turin (IT)
- University of Padua (IT)
- National Institutes of Health (US)
- Novartis (Switzerland) (CH)
- University of Oxford (GB)
- Corresponding author
- Caretti, Giuseppina
- ORCID
- Venue
- Nature Communications
- Published
- 2017-11-22
- Volume
- 8
- Issue
- 1
- Pages
- 1707-1707
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5700099
- OpenAlex
- W2768531312
- Cited by
- 101
- References
- 71
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 5 · 2023: 16 · 2022: 9 · 2021: 15 · 2020: 18 · 2019: 14 · 2018: 11
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, cc-by)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by-nc-nd)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, cc-by)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Funders
- Wellcome Trust (106169/Z/14/Z, 095751/Z/11/Z)
- Associazione Italiana per la Ricerca sul Cancro
- Fondazione Italiana per la Ricerca sul Cancro
- National Institutes of Health
- Medical Research Council (MR/N010051/1)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Keywords
- cancer cachexia, BRD4, BET proteins, JQ1, BET inhibitors, muscle atrophy, adipose tissue wasting, interleukin-6, AMPK signaling, FOXO3, epigenetic regulation, survival
- MeSH terms
- Forkhead Box Protein O3, Bromodomain Containing Proteins, Animals, Azepines, Cachexia, Gene Expression Regulation, Humans, Male, Muscular Atrophy, Neoplasms, Experimental, Nuclear Proteins, Transcription Factors, Triazoles, Interleukin-6, Muscle, Skeletal, Cell Cycle Proteins, Epigenesis, Genetic, Cell Line, Tumor, Mice, Metabolic Networks and Pathways, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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