LeCluyse, Edward L.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 1,280

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies

Hewitt, N. J., Gómez Lechón, M. J., Houston, J. B., Hallifax, D., Brown, H. S., Maurel, P., Kenna, J. G., Gustavsson, L., Lohmann, C., Skonberg, C., et al. (2007) · Drug Metabolism Reviews

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 735

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation

LeCluyse, E. L. (2001) · European Journal of Pharmaceutical Sciences

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 477

Organotypic liver culture models: meeting current challenges in toxicity testing

LeCluyse, E. L., Witek, R. P., Andersen, M. E., & Powers, M. J. (2012) · Critical Reviews in Toxicology

Drug-Induced Hepatotoxicity and ProtectionAnimal testing and alternatives

Cited by 363

Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration

LeCluyse, E. L., Audus, K. L., & Hochman, J. H. (1994) · American Journal of Physiology-Cell Physiology

Liver physiology and pathologyCellular Mechanics and Interactions

Cited by 266

Correlation of Biliary Excretion in Sandwich-Cultured Rat Hepatocytes and In Vivo in Rats

Liu, X., Chism, J. P., LeCluyse, E. L., Brouwer, K. R., & Brouwer, K. L. R. (1999) · Drug Metabolism and Disposition

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 228

Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration

Liu, X., LeCluyse, E. L., Brouwer, K. R., Gan, L.-S. L., Lemasters, J. J., Stieger, B., Meier, P. J., & Brouwer, K. L. R. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Drug Transport and Resistance MechanismsLiver physiology and pathology

Cited by 226

Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition

Sahi, J., Black, C. B., Hamilton, G. A., Zheng, X., Jolley, S., Rose, K. A., Gilbert, D., LeCluyse, E. L., & Sinz, M. W. (2003) · Drug Metabolism and Disposition

Pharmacogenetics and Drug MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 113

Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro

Dash, A., Simmers, M. B., Deering, T. G., Berry, D. J., Feaver, R. E., Hastings, N. E., Pruett, T. L., LeCluyse, E. L., Blackman, B. R., & Wamhoff, B. R. (2013) · American Journal of Physiology-Cell Physiology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 108

Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity

Rose, K. A., Holman, N. S., Green, A. M., Andersen, M. E., & LeCluyse, E. L. (2016) · Journal of Pharmaceutical Sciences

Drug-Induced Hepatotoxicity and ProtectionImmunotoxicology and immune responses

Cited by 99

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice

Harrill, J. A., Hukkanen, R. R., Lawson, M., Martin, G., Gilger, B., Soldatow, V., LeCluyse, E. L., Budinsky, R. A., Rowlands, J. C., & Thomas, R. S. (2013) · Toxicology and Applied Pharmacology

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 83