Pagano, Michele

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

Baldin, V, Lukas, J., Marcote, M. J., Pagano, M., & Draetta, G. (1993) · Genes & Development

Cancer-related Molecular PathwaysSignaling Pathways in Disease

Cited by 1,614

Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

Zheng, N., Schulman, B. A., Song, L., Miller, J. J., Jeffrey, P. D., Wang, P., Chu, C., Koepp, D. M., Elledge, S. J., Pagano, M., et al. (2002) · Nature

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 1,507

The SCF ubiquitin ligase: insights into a molecular machine

Cardozo, T., & Pagano, M. (2004) · Nature Reviews Molecular Cell Biology

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 1,114

S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth

Dorrello, N. V., Peschiaroli, A., Guardavaccaro, D., Colburn, N. H., Sherman, N. E., & Pagano, M. (2006) · Science

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 731

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

Lignitto, L., LeBoeuf, S. E., Homer, H., Jiang, S., Askenazi, M., Karakousi, T. R., Pass, H. I., Bhutkar, A. J., Tsirigos, A., Ueberheide, B., et al. (2019) · Cell

Genomics, phytochemicals, and oxidative stressMechanisms of cancer metastasis

Cited by 573

Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

Busino, L., Donzelli, M., Chiesa, M., Guardavaccaro, D., Ganoth, D., Valerio Dorrello, N., Hershko, A., Pagano, M., & Draetta, G. F. (2003) · Nature

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 447

The Cdc14B-Cdh1-Plk1 Axis Controls the G2 DNA-Damage-Response Checkpoint

Bassermann, F., Frescas, D., Guardavaccaro, D., Busino, L., Peschiaroli, A., & Pagano, M. (2008) · Cell

DNA Repair MechanismsMicrotubule and mitosis dynamics

Cited by 397

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts

Pagano, M., Theodoras, A. M., Tam, S. W., & Draetta, G. F. (1994) · Genes & Development

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 294

SCFβTrCP-Mediated Degradation of Claspin Regulates Recovery from the DNA Replication Checkpoint Response

Peschiaroli, A., Dorrello, N. V., Guardavaccaro, D., Venere, M., Halazonetis, T., Sherman, N. E., & Pagano, M. (2006) · Molecular Cell

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 289

JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes

Frescas, D., Guardavaccaro, D., Bassermann, F., Koyama-Nasu, R., & Pagano, M. (2007) · Nature

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 284

PTEN Counteracts FBXL2 to Promote IP3R3- and Ca2+-Mediated Apoptosis Limiting Tumour Growth

Kuchay, S., Giorgi, C., Simoneschi, D., Pagan, J., Missiroli, S., Saraf, A., Florens, L., Washburn, M. P., Collazo-Lorduy, A., Castillo-Martin, M., et al. (2017) · Nature

Cell death mechanisms and regulationIon Channels and Receptors

Cited by 251

SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

Xing, W., Busino, L., Hinds, T. R., Marionni, S. T., Saifee, N. H., Bush, M. F., Pagano, M., & Zheng, N. (2013) · Nature

Circadian rhythm and melatoninLight effects on plants

Cited by 234

An Rb-Skp2-p27 Pathway Mediates Acute Cell Cycle Inhibition by Rb and Is Retained in a Partial-Penetrance Rb Mutant

Ji, P., Jiang, H., Rekhtman, K., Bloom, J., Ichetovkin, M., Pagano, M., & Zhu, L. (2004) · Molecular Cell

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 170

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer

Deng, J., Thennavan, A., Dolgalev, I., Chen, T., Li, J., Marzio, A., Poirier, J. T., Peng, D. H., Bulatovic, M., Mukhopadhyay, S., et al. (2021) · Nature Cancer

Cancer Immunotherapy and BiomarkersAutophagy in Disease and Therapy

Cited by 140

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4

Nguyen-Dien, G. T., Townsend, B., Kulkarni, P., Kozul, K.-L., Ooi, S. S., Eldershaw, D., Weeratunga, S., Liu, M., Jones, M. J., Millard, S. S., et al. (2024) · EMBO Reports

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 30

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

Nguyen-Dien, G. T., Townsend, B., Kulkarni, P. G., Kozul, K.-L., Ooi, S. S., Eldershaw, D. N., Weeratunga, S., Liu, M., Jones, M. J., Millard, S. S., et al. (2024) · EMBO Reports

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 30