The SCF ubiquitin ligase: insights into a molecular machine

THE UBIQUITIN SYSTEM

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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The leucine-rich repeat as a protein recognition motif

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

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SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box

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The WD repeat: a common architecture for diverse functions

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F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

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Recycling the Cell Cycle

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The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

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Small molecule modulation of Smoothened activity

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The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitroPreprint

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Cyclin E-CDK2 is a regulator of p27Kip1.Preprint

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The Anaphase-Promoting Complex

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p.

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Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function

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Structure of a c-Cbl–UbcH7 Complex

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p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27

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Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

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Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCF Fbw7 Ubiquitin Ligase

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A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

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The F-box protein family.

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Proteasomes and their kin: proteases in the machine age

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication

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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

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Back to the Future with Ubiquitin

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Phosphorylation‐dependent degradation of the cyclin‐dependent kinase inhibitor p27Kip1

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The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell

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Whose end is destruction: cell division and the anaphase-promoting complexPreprint

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Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex

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The ubiquitin system

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Structure of a β-TrCP1-Skp1-β-Catenin Complex

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Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formationPreprint

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

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Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity.

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The spindle checkpoint: structural insights into dynamic signalling

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An F‐box protein, FWD1, mediates ubiquitin‐dependent proteolysis of β‐catenin

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Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase

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Control of the SCFSkp2–Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase

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BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3

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Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase

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Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

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The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27

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Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases

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Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

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The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin

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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

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Nedd8 on cullin: building an expressway to protein destruction

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COP9 Signalosome

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Emi1 Is a Mitotic Regulator that Interacts with Cdc20 and Inhibits the Anaphase Promoting Complex

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Binding of small molecules to an adaptive protein–protein interface

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Identification of a family of human F-box proteins

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Multisite Phosphorylation by Cdk2 and GSK3 Controls Cyclin E Degradation

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Skp2-Mediated Degradation of p27 Regulates Progression into Mitosis

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A family of mammalian F-box proteins

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A CDK-Independent Function of Mammalian Cks1

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Control of Meiotic and Mitotic Progression by the F Box Protein β-Trcp1 In Vivo

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E3 ubiquitin ligase that recognizes sugar chains

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SCF^β-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

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BTB/POZ Domain Proteins Are Putative Substrate Adaptors for Cullin 3 Ubiquitin Ligases

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Prophase Destruction of Emi1 by the SCFβTrCP/Slimb Ubiquitin Ligase Activates the Anaphase Promoting Complex to Allow Progression beyond Prometaphase

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E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APCCdh1

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Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

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Proteasome-Mediated Degradation of p21 via N-Terminal Ubiquitinylation

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p27 binds cyclin–CDK complexes through a sequential mechanism involving binding-induced protein folding

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Split-Hand/Split-Foot Malformation Is Caused by Mutations in the p63 Gene on 3q27

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Ubiquitin Ligases and the Immune Response

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Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT Domain E3 Ligase

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Structural principles of leucine‐rich repeat (LRR) proteins

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Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

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