Diehl, J. Alan

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

Diehl, J. A., Cheng, M., Roussel, M. F., & Sherr, C. J. (1998) · Genes & Development

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 2,130

The p21Cip1 and p27Kip1 CDK ‘inhibitors’ are essential activators of cyclin D‐dependent kinases in murine fibroblasts

Cheng, M., Olivier, P., Diehl, J. A., Fero, M., Roussel, M. F., Roberts, J. M., & Sherr, C. J. (1999) · The EMBO Journal

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 1,142

The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase

Cullinan, S. B., Gordan, J. D., Jin, J., Harper, J. W., & Diehl, J. A. (2004) · Molecular and Cellular Biology

Genomics, phytochemicals, and oxidative stressUbiquitin and proteasome pathways

Cited by 986

HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity

Gordan, J. D., Bertout, J. A., Hu, C.-J., Diehl, J. A., & Simon, M. C. (2007) · Cancer Cell

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 781

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

Diehl, J. A., Zindy, F., & Sherr, C. J. (1997) · Genes & Development

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 746

Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway

Cullinan, S. B., & Diehl, J. A. (2006) · The International Journal of Biochemistry & Cell Biology

Endoplasmic Reticulum Stress and DiseaseGenomics, phytochemicals, and oxidative stress

Cited by 554

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation

Alt, J. R., Cleveland, J. L., Hannink, M., & Diehl, J. A. (2000) · Genes & Development

Cancer-related Molecular PathwaysWnt/β-catenin signaling in development and cancer

Cited by 535

Nuclear cyclin D1: an oncogenic driver in human cancer

Kim, J. K., & Diehl, J. A. (2009) · Journal of Cellular Physiology

Cancer-related Molecular PathwaysSignaling Pathways in Disease

Cited by 413

HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

Qiu, B., Ackerman, D., Sanchez, D. J., Li, B., Ochocki, J. D., Grazioli, A., Bobrovnikova-Marjon, E., Diehl, J. A., Keith, B., & Simon, M. C. (2015) · Cancer Discovery

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 394

Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex

Lin, D. I., Barbash, O., Kumar, K. G. S., Weber, J. D., Harper, J. W., Klein-Szanto, A. J. P., Rustgi, A., Fuchs, S. Y., & Diehl, J. A. (2006) · Molecular Cell

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 349

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

Wong, G. S., Zhou, J., Liu, J. B., Wu, Z., Xu, X., Li, T., Xu, D., Schumacher, S. E., Puschhof, J., McFarland, J., et al. (2018) · Nature Medicine

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 266

Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival

Liu, L., Wise, D. R., Diehl, J. A., & Simon, M. C. (2008) · Journal of Biological Chemistry

Endoplasmic Reticulum Stress and DiseasePI3K/AKT/mTOR signaling in cancer

Cited by 206

Induction of therapeutic senescence in vemurafenib-resistant melanoma by extended inhibition of CDK4/6

Yoshida, A., Lee, E. K., & Diehl, J. A. (2016) · Cancer Research

Melanoma and MAPK PathwaysAdvanced Breast Cancer Therapies

Cited by 153

PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers

Li, Y., Chitnis, N., Nakagawa, H., Kita, Y., Natsugoe, S., Yang, Y., Li, Z., Wasik, M., Klein-Szanto, A. J. P., Rustgi, A. K., et al. (2015) · Cancer Discovery

Cancer-related gene regulationCancer-related Molecular Pathways

Cited by 143

Mutations in Fbx4 Inhibit Dimerization of the SCFFbx4 Ligase and Contribute to Cyclin D1 Overexpression in Human Cancer

Barbash, O., Zamfirova, P., Lin, D. I., Chen, X., Yang, K., Nakagawa, H., Lu, F., Rustgi, A. K., & Diehl, J. A. (2008) · Cancer Cell

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 140

Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication

Aggarwal, P., Lessie, M. D., Lin, D. I., Pontano, L., Gladden, A. B., Nuskey, B., Goradia, A., Wasik, M. A., Klein-Szanto, A. J. P., Rustgi, A. K., et al. (2007) · Genes & Development

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 132

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2

Zhang, H., Fillmore Brainson, C., Koyama, S., Redig, A. J., Chen, T., Li, S., Gupta, M., Garcia-de-Alba, C., Paschini, M., Herter-Sprie, G. S., et al. (2017) · Nature Communications

Epigenetics and DNA MethylationCancer Cells and Metastasis

Cited by 127

Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-Invasive Signature in Esophageal Cancer

Michaylira, C. Z., Wong, G. S., Miller, C. G., Gutierrez, C. M., Nakagawa, H., Hammond, R., Klein-Szanto, A. J., Lee, J.-S., Kim, S. B., Herlyn, M., et al. (2010) · Cancer Research

Bone and Dental Protein StudiesCell Adhesion Molecules Research

Cited by 117

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression

Katlinskaya, Y. V., Katlinski, K. V., Yu, Q., Ortiz, A., Beiting, D. P., Brice, A., Davar, D., Sanders, C., Kirkwood, J. M., Rui, H., et al. (2016) · Cell Reports

Telomeres, Telomerase, and Senescenceinterferon and immune responses

Cited by 108

Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase

Diehl, J. A., Yang, W., Rimerman, R. A., Xiao, H., & Emili, A. (2003) · Molecular and Cellular Biology

Heat shock proteins researchCancer-related Molecular Pathways

Cited by 97

The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases

Rozpędek-Kamińska, W., Siwecka, N., Wawrzynkiewicz, A., Wojtczak, R., Pytel, D., Diehl, J. A., & Majsterek, I. (2020) · International Journal of Molecular Sciences

Endoplasmic Reticulum Stress and DiseaseAlzheimer's disease research and treatments

Cited by 84

Consequence of the tumor-associated conversion to cyclin D1b

Augello, M. A., Berman‐Booty, L. D., Carr, R., Yoshida, A., Dean, J. L., Schiewer, M. J., Feng, F. Y., Tomlins, S. A., Gao, E., Koch, W. J., et al. (2015) · EMBO Molecular Medicine

Cancer-related Molecular PathwaysSignaling Pathways in Disease

Cited by 23