Cited by 117Bone and Dental Protein StudiesCell Adhesion Molecules ResearchEsophageal Cancer Research and Treatment

Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-Invasive Signature in Esophageal Cancer

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Michaylira, Carmen Z., Wong, Gabrielle S., Miller, Charles G., Gutierrez, Christie M., Nakagawa, Hiroshi, Hammond, Rachel, Klein-Szanto, Andres J., Lee, Ju-Seog +5 more·2010·Cancer Research

Published version of a preprint

Abstract

Human squamous cell cancers are the most common epithelially derived malignancies. One example is esophageal squamous cell carcinoma (ESCC), which is associated with a high mortality rate that is related to a propensity for invasion and metastasis. Here, we report that periostin, a highly expressed cell adhesion molecule, is a key component of a novel tumor-invasive signature obtained from an organotypic culture model of engineered ESCC. This tumor-invasive signature classifies with human ESCC microarrays, underscoring its utility in human cancer. Genetic modulation of periostin promotes tumor cell migration and invasion as revealed in gain-of-loss and loss-of-function experiments. Inhibition of epidermal growth factor receptor signaling and restoration of wild-type p53 function were each found to attenuate periostin, suggesting the interdependence of two common genetic alterations with periostin function. Collectively, our studies reveal periostin as an important mediator of ESCC tumor invasion and they indicate that organotypic (three-dimensional) culture can offer an important tool to discover novel biological effectors in cancer. Cancer Res; 70(13); 5281–92. ©2010 AACR.

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  • Periostin boosts the invasiveness of esophageal tumors and could be useful in the search for new therapeutic targets for esophageal cancer.

    “Michaylira et al . 67 used 3D cell culture techniques to find that another cell adhesion molecule, periostin, which boosts the invasiveness of esophageal tumors, could be useful in search for new therapeutic targets for esophageal cancer.”

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Authors
Michaylira, C. Z., Wong, G. S., Miller, C. G., Gutierrez, C. M., Nakagawa, H., Hammond, R., Klein-Szanto, A. J., Lee, J.-S., Kim, S. B., Herlyn, M., Diehl, J. A., Gimotty, P., & Rustgi, A. K.
Affiliations
  • The Wistar Institute (US)
  • Authors' Affiliations: 1Division of Gastroenterology, Departments of 2Medicine, 3Genetics, and 4Cancer Biology, 5Abramson Cancer Center, and 6Division of Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania; 7Division of Basic Science, Tumor Cell Biology, Fox Chase Cancer Center; and 8Wistar Institute, Philadelphia, Pennsylvania; and 9Departent of Systems Biology, M.D. Anderson Cancer Center, Houston, Texas
Corresponding author
Rustgi, Anil K.
Venue
Cancer Research
Published
2010-06-30
Volume
70
Issue
13
Pages
5281-5292
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
OpenAlex
W2123522555
Cited by
117
References
34
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 11 · 2013: 13 · 2012: 8
FWCI
7.61
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Cancer Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Cancer Institute (P01CA098101, T32CA115299, P30CA016520)
  • National Institute of Diabetes and Digestive and Kidney Diseases (F32DK075230, P30DK050306)
Topics
  • Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
Keywords
periostin, esophageal squamous cell carcinoma, tumor invasion, tumor microenvironment, adhesion molecules, organotypic culture, tumor cell migration, epidermal growth factor receptor signaling, p53, metastasis
MeSH terms
Carcinoma, Squamous Cell, Esophageal Neoplasms, Humans, Neoplasm Invasiveness, Tumor Cells, Cultured, Cell Adhesion Molecules, Tumor Suppressor Protein p53, Telomerase, Gene Expression Profiling, ErbB Receptors

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