Shimomura, Kenju

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Brereton, M. F., Iberl, M., Shimomura, K., Zhang, Q., Adriaenssens, A. E., Proks, P., Spiliotis, I. I., Dace, W., Mattis, K. K., Ramracheya, R., et al. (2014) · Nature Communications

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 259

Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects

Ellard, S., Flanagan, S. E., Girard, C. A., Patch, A.-M., Harries, L. W., Parrish, A., Edghill, E. L., Mackay, D. J. G., Proks, P., Shimomura, K., et al. (2007) · The American Journal of Human Genetics

Pancreatic function and diabetesIon channel regulation and function

Cited by 215

3‐D structural and functional characterization of the purified KATP channel complex Kir6.2–SUR1

Mikhailov, M. V., Campbell, J. D., de Wet, H., Shimomura, K., Zadek, B., Collins, R. F., Sansom, M. S., Ford, R. C., & Ashcroft, F. M. (2005) · The EMBO Journal

Ion channel regulation and functionATP Synthase and ATPases Research

Cited by 168

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Brereton, M. F., Rohm, M., Shimomura, K., Holland, C., Tornovsky-Babeay, S., Dadon, D., Iberl, M., Chibalina, M. V., Lee, S., Glaser, B., et al. (2016) · Nature Communications

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 124

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes

Girard, C. A., Wunderlich, F. T., Shimomura, K., Collins, S., Kaizik, S., Proks, P., Abdulkader, F., Clark, A., Ball, V., Zubcevic, L., et al. (2008) · Journal of Clinical Investigation

Pancreatic function and diabetesIon channel regulation and function

Cited by 105

Long-Term Exposure to Glucose and Lipids Inhibits Glucose-Induced Insulin Secretion Downstream of Granule Fusion With Plasma Membrane

Olofsson, C. S., Collins, S., Bengtsson, M., Eliasson, L., Salehi, A., Shimomura, K., Tarasov, A., Holm, C., Ashcroft, F., & Rorsman, P. (2007) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 87

Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas

Maejima, Y., Rita, R. S., Santoso, P., Aoyama, M., Hiraoka, Y., Nishimori, K., Gantulga, D., Shimomura, K., & Yada, T. (2015) · Neuroendocrinology

Regulation of Appetite and ObesityNeuroendocrine regulation and behavior

Cited by 81

The deletion of glucagon-like peptide-1 receptors expressing neurons in the dorsomedial hypothalamic nucleus disrupts the diurnal feeding pattern and induces hyperphagia and obesity

Maejima, Y., Yokota, S., Shimizu, M., Horita, S., Kobayashi, D., Hazama, A., & Shimomura, K. (2021) · Nutrition & Metabolism

Regulation of Appetite and ObesityCircadian rhythm and melatonin

Cited by 21