Ihara, Masafumi

Stroke injury, cognitive impairment and vascular dementia

Kalaria, R. N., Akinyemi, R., & Ihara, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

Cited by 647

White Matter Lesions and Glial Activation in a Novel Mouse Model of Chronic Cerebral Hypoperfusion

Shibata, M., Ohtani, R., Ihara, M., & Tomimoto, H. (2004) · Stroke

Neurological Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 583

Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study

Skrobot, O. A., Black, S. E., Chen, C., DeCarli, C., Erkinjuntti, T., Ford, G. A., Kalaria, R. N., O'Brien, J., Pantoni, L., Pasquier, F., et al. (2018) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

Cited by 431

Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

Okamoto, Y., Yamamoto, T., Kalaria, R. N., Senzaki, H., Maki, T., Hase, Y., Kitamura, A., Washida, K., Yamada, M., Ito, H., et al. (2012) · Acta Neuropathologica

Intracerebral and Subarachnoid Hemorrhage ResearchNeurological Disease Mechanisms and Treatments

Cited by 249

The Vascular Impairment of Cognition Classification Consensus Study

Skrobot, O. A., O'Brien, J., Black, S., Chen, C., DeCarli, C., Erkinjuntti, T., Ford, G. A., Kalaria, R. N., Pantoni, L., Pasquier, F., et al. (2017) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

Cited by 242

Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat

Wakita, H., Tomimoto, H., Akiguchi, I., Matsuo, A., Lin, J.-X., Ihara, M., & McGeer, P.-L. (2002) · Brain Research

Neurological Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 197

Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia

Chen, A., Akinyemi, R. O., Hase, Y., Firbank, M. J., Ndung’u, M. N., Foster, V., Craggs, L. J. L., Washida, K., Okamoto, Y., Thomas, A. J., et al. (2016) · Brain

Cerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

Cited by 172

Neuropathological correlates of temporal pole white matter hyperintensities in CADASIL

Yamamoto, Y., Ihara, M., Tham, C., Low, R. W. C., Slade, J. Y., Moss, T., Oakley, A. E., Polvikoski, T., & Kalaria, R. N. (2009) · Stroke

Cerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

Cited by 155

Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer’s disease and vascular dementia

Akinyemi, R., Mukaetova-Ladinska, E., Attems, J., Ihara, M., & Kalaria, R. (2013) · Current Alzheimer Research

Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

Cited by 152

microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain

Kim, J., Yoon, H., Horie, T., Burchett, J. M., Restivo, J. L., Rotllan, N., Ramírez, C. M., Verghese, P. B., Ihara, M., Hoe, H.-S., et al. (2015) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsMicroRNA in disease regulation

Cited by 128

Chronic cerebral hypoperfusion induces MMP-2 but not MMP-9 expression in the microglia and vascular endothelium of white matter

Ihara, M., Tomimoto, H., Kinoshita, M., Oh, J., Noda, M., Wakita, H., Akiguchi, I., & Shibasaki, H. (2001) · Journal of Cerebral Blood Flow & Metabolism

Neurological Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 115

Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy

Saito, S., Yamamoto, Y., Maki, T., Hattori, Y., Ito, H., Mizuno, K., Harada-Shiba, M., Kalaria, R. N., Fukushima, M., Takahashi, R., et al. (2017) · Acta Neuropathologica Communications

Alzheimer's disease research and treatmentsIntracerebral and Subarachnoid Hemorrhage Research

Cited by 110

Chronic cerebral hypoperfusion accelerates amyloid β deposition in APPSwInd transgenic mice

Kitaguchi, H., Tomimoto, H., Ihara, M., Shibata, M., Uemura, K., Kalaria, R. N., Kihara, T., Asada-Utsugi, M., Kinoshita, A., & Takahashi, R. (2009) · Brain Research

Alzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Cited by 108

Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer’s Disease: What are the Roadblocks and How Can They Be Overcome?

Banik, A., Brown, R. E., Bamburg, J., Lahiri, D. K., Khurana, D., Friedland, R. P., Chen, W., Ding, Y., Mudher, A., Padjen, A. L., et al. (2015) · Journal of Alzheimer’s Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 102

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research

METACOHORTS Consortium, Dichgans, M., Wardlaw, J., Smith, E., Zietemann, V., Seshadri, S., Sachdev, P., Biessels, G. J., Fazekas, F., Benavente, O., et al. (2016) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

Cited by 101

Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice

Maki, T., Ihara, M., Fujita, Y., Nambu, T., Miyashita, K., Yamada, M., Washida, K., Nishio, K., Ito, H., Harada, H., et al. (2011) · Stroke

Neurological Disease Mechanisms and TreatmentsNeuropeptides and Animal Physiology

Cited by 88

Interaction between cerebrovascular disease and Alzheimer pathology

Saito, S., & Ihara, M. (2016) · Current Opinion in Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 69

Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment

Yasuno, F., Kazui, H., Yamamoto, A., Morita, N., Kajimoto, K., Ihara, M., Taguchi, A., Matsuoka, K., Kosaka, J., Tanaka, T., et al. (2015) · Neurobiology of Aging

Functional Brain Connectivity StudiesDementia and Cognitive Impairment Research

Cited by 44

The Nairobi Declaration—reducing the burden of dementia in low- and middle-income countries (LMICs): declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs

Maestre, G., Carrillo, M., Kalaria, R., Acosta, D., Adams, L., Adoukonou, T., Akinwande, K., Akinyemi, J., Akinyemi, R., Akpa, O., et al. (2023) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchMental Health Treatment and Access

Cited by 31

Disease Severity Staging System for NOTCH3 -Associated Small Vessel Disease, Including CADASIL

Gravesteijn, G., Rutten, J. W., Cerfontaine, M. N., Hack, R. J., Liao, Y.-C., Jolly, A. A., Guey, S., Hsu, S.-L., Park, J.-Y., Yuan, Y., et al. (2025) · JAMA Neurology

Cerebrovascular and genetic disordersGenetic Neurodegenerative Diseases

Cited by 25

Small artery dementia in Japan: radiological differences between CADASIL, leukoaraiosis and Binswanger’s disease

Tomimoto, H., Ohtani, R., Wakita, H., Lin, J.-X., Ihara, M., Miki, Y., Oshima, F., Murata, T., Ishibashi, K., Suenaga, T., et al. (2006) · Dementia and Geriatric Cognitive Disorders

Cerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

Cited by 20

Pivotal trial of low-intensity pulsed ultrasound therapy for early Alzheimer's disease: Rationale and design

Shimokawa, H., Akishita, M., Ihara, M., Teramukai, S., Ishiki, A., Nagai, Y., & Fukushima, M. (2025) · Journal of Alzheimer's Disease Reports

Alzheimer's disease research and treatmentsUltrasound and Hyperthermia Applications

Cited by 3

Baseline characteristics of patients with early Alzheimer's disease enrolled in the pivotal trial of low-intensity pulsed ultrasound (LIPUS-AD)

Shimokawa, H., Akishita, M., Asada, T., Katayama, S., Hattori, Y., Yakushiji, Y., Taki, Y., Murai, H., Boku, Y., Tsujimoto, M., et al. (2025) · Journal of Alzheimer's Disease Reports

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 0