Lin, Peter Bor-Chian

Comprehensive evaluation of the 5xFAD mouse model for preclinical testing applications: A MODEL-AD study.

Oblak, A. L., Lin, P. B., Kotredes, K. P., Pandey, R. S., Garceau, D., Williams, H. M., Uyar, A., O’Rourke, R., O’Rourke, S., Ingraham, C., et al. (2021) · Frontiers in Aging Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 325

CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease

Puntambekar, S. S., Moutinho, M., Lin, P. B.-C., Jadhav, V., Tumbleson-Brink, D., Balaji, A., Benito, M. A., Xu, G., Oblak, A., Lasagna-Reeves, C. A., et al. (2022) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 113

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia

Tsai, A. P., Lin, P. B.-C., Dong, C., Moutinho, M., Casali, B. T., Liu, Y., Lamb, B. T., Landreth, G. E., Oblak, A. L., & Nho, K. (2021) · Neurobiology of Disease

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 104

The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease

Moutinho, M., Puntambekar, S. S., Tsai, A. P., Coronel, I., Lin, P. B., Casali, B. T., Martinez, P., Oblak, A. L., Lasagna-Reeves, C. A., Lamb, B. T., et al. (2022) · Science Translational Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 92

PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease

Tsai, A. P., Dong, C., Lin, P. B.-C., Messenger, E. J., Casali, B. T., Moutinho, M., Liu, Y., Oblak, A. L., Lamb, B. T., Landreth, G. E., et al. (2022) · Genome Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 92

Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease

Tsai, A. P., Dong, C., Lin, P. B.-C., Oblak, A. L., Viana Di Prisco, G., Wang, N., Hajicek, N., Carr, A. J., Lendy, E. K., Hahn, O., et al. (2023) · Immunity

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 71

Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H

Kotredes, K. P., Oblak, A., Pandey, R. S., Lin, P. B.-C., Garceau, D., Williams, H., Uyar, A., O’Rourke, R., O’Rourke, S., Ingraham, C., et al. (2021) · Frontiers in Aging Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 66

INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease

Lin, P. B., Tsai, A. P., Soni, D., Lee‐Gosselin, A., Moutinho, M., Puntambekar, S. S., Landreth, G. E., Lamb, B. T., & Oblak, A. L. (2023) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 54

Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis

Karahan, H., Smith, D. C., Kim, B., Dabin, L. C., Al-Amin, M. M., Wijeratne, H. R. S., Pennington, T., Viana di Prisco, G., McCord, B., Lin, P. B.-C., et al. (2021) · Science Advances

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 53

Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice

Oblak, A. L., Kotredes, K. P., Pandey, R. S., Reagan, A. M., Ingraham, C., Perkins, B., Lloyd, C., Baker, D., Lin, P. B., Soni, D. M., et al. (2022) · Frontiers in Aging Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 23

Current insights into apolipoprotein E and the immune response in Alzheimer's disease

Lin, P. B., & Holtzman, D. M. (2024) · Immunological Reviews

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 19

PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology

Messenger, E. J., Baar, S. A., Bedford, L. M., Tsai, A. P., Lin, P. B., Ferguson, C. A., Xu, G., Wallace, A., Landreth, G. E., Lamb, B. T., et al. (2025) · Alzheimer's & Dementia

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 16

Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging

Maharjan, S., Tsai, A. P., Lin, P. B., Ingraham, C., Jewett, M. R., Landreth, G. E., Oblak, A. L., & Wang, N. (2022) · Frontiers in Neuroscience

Advanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and Applications

Cited by 15

Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy

Soni, D. M., Lin, P. B., Lee‐Gosselin, A., Lloyd, C. D., Mason, E., Ingraham, C. M., Perkins, A., Moutinho, M., Lamb, B. T., Chu, S., et al. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 14

PLCG2 as a Risk Factor for Alzheimer's Disease.

Tsai, A. P., Dong, C., Preuss, C., Moutinho, M., Lin, P. B.-C., Hajicek, N., Sondek, J., Bissel, S. J., Oblak, A. L., Carter, G. W., et al. (2020)

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 7

Optimization of SHIP1 Inhibitors for the treatment of Alzheimer’s disease

Jesudason, C. D., Lin, P. B., Soni, D., Perkins, B. M., Lee‐Gosselin, A., Ingraham, C. M., Hamilton, W., Mason, E. R., Jordi, O. E., Souza, S., et al. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1

Impact of PLCG2 expression on Microglial Biology and Disease Pathogenesis in Alzheimer’s Disease

Tsai, A. P., Lin, P. B., Dong, C., Moutinho, M., Liu, Y., Bissel, S. J., Oblak, A. L., Nho, K., Lamb, B. T., & Landreth, G. E. (2021) · Alzheimer's & Dementia

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 1