Dhekne, Herschel S

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Dhekne, H. S., Yanatori, I., Gomez, R. C., Tonelli, F., Diez, F., Schüle, B., Steger, M., Alessi, D. R., & Pfeffer, S. R. (2018) · eLife

Parkinson's Disease Mechanisms and TreatmentsGenetic and Kidney Cyst Diseases

Cited by 240

CD63 is regulated by iron via the IRE-IRP system and is important for ferritin secretion by extracellular vesicles

Yanatori, I., Richardson, D. R., Dhekne, H. S., Toyokuni, S., & Kishi, F. (2021) · Blood

Extracellular vesicles in diseaseIron Metabolism and Disorders

Cited by 148

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Khan, S. S., Sobu, Y., Dhekne, H. S., Tonelli, F., Berndsen, K., Alessi, D. R., & Pfeffer, S. R. (2021) · eLife

Parkinson's Disease Mechanisms and TreatmentsGenetic and Kidney Cyst Diseases

Cited by 93

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

Dhekne, H. S., Tonelli, F., Yeshaw, W. M., Chiang, C. Y., Limouse, C., Jaimon, E., Purlyte, E., Alessi, D. R., & Pfeffer, S. R. (2023) · eLife

Parkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

Cited by 76

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

Vides, E. G., Adhikari, A., Chiang, C. Y., Lis, P., Purlyte, E., Limouse, C., Shumate, J. L., Spínola-Lasso, E., Dhekne, H. S., Alessi, D. R., et al. (2022) · eLife

Parkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

Cited by 63

A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation

Vides, E. G., Adhikari, A., Chiang, C. Y., Lis, P., Purlyte, E., Limouse, C., Shumate, J. L., Spínola-Lasso, E., Dhekne, H. S., Alessi, D. R., et al. (2022) · eLife

Parkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

Cited by 63