Nemeth, Elizabeta

Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin

Aschemeyer, S., Qiao, B., Stefanova, D., Valore, E. V., Sek, A. C., Ruwe, T. A., Vieth, K. R., Jung, G., Casu, C., Rivella, S., et al. (2018) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 325

Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs

Rivera, S., Nemeth, E., Gabayan, V., Lopez, M. A., Farshidi, D., & Ganz, T. (2005) · Blood

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 308

Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia

Kautz, L., Jung, G., Du, X., Gabayan, V., Chapman, J., Nasoff, M., Nemeth, E., & Ganz, T. (2015) · Blood

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 306

The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study

Nemeth, E., Preza, G. C., Jung, C.-L., Kaplan, J., Waring, A. J., & Ganz, T. (2006) · Blood

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 273

Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4

Lin, L., Valore, E. V., Nemeth, E., Goodnough, J. B., Gabayan, V., & Ganz, T. (2007) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 267

Proinflammatory state, hepcidin, and anemia in older persons

Ferrucci, L., Semba, R. D., Guralnik, J. M., Ershler, W. B., Bandinelli, S., Patel, K. V., Sun, K., Woodman, R. C., Andrews, N. C., Cotter, R. J., et al. (2010) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 245

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

Preza, G. C., Ruchala, P., Pinon, R., Ramos, E., Qiao, B., Peralta, M. A., Sharma, S., Waring, A., Ganz, T., & Nemeth, E. (2011) · Journal of Clinical Investigation

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 234

The molecular basis of ferroportin-linked hemochromatosis

De Domenico, I., Ward, D. M., Nemeth, E., Vaughn, M. B., Musci, G., Ganz, T., & Kaplan, J. (2005) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 230

Hepcidin-Induced Hypoferremia Is a Critical Host Defense Mechanism against the Siderophilic Bacterium Vibrio vulnificus

Arezes, J., Jung, G., Gabayan, V., Valore, E., Ruchala, P., Gulig, P. A., Ganz, T., Nemeth, E., & Bulut, Y. (2015) · Cell Host & Microbe

Iron Metabolism and DisordersVibrio bacteria research studies

Cited by 227

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

Gardenghi, S., Ramos, P., Marongiu, M. F., Melchiori, L., Breda, L., Guy, E., Muirhead, K., Rao, N., Roy, C. N., Andrews, N. C., et al. (2010) · Journal of Clinical Investigation

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 220

Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis

Ramos, E., Ruchala, P., Goodnough, J. B., Kautz, L., Preza, G. C., Nemeth, E., & Ganz, T. (2012) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 213

Hepcidin and Host Defense against Infectious Diseases

Michels, K., Nemeth, E., Ganz, T., & Mehrad, B. (2015) · PLOS Pathogens

Iron Metabolism and DisordersImmune Response and Inflammation

Cited by 205

Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload

Schwartz, A. J., Das, N. K., Ramakrishnan, S. K., Jain, C., Jurkovic, M. T., Wu, J., Nemeth, E., Lakhal-Littleton, S., Colacino, J. A., & Shah, Y. M. (2018) · Journal of Clinical Investigation

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 203

Effects of maternal iron status on placental and fetal iron homeostasis

Sangkhae, V., Fisher, A. L., Wong, S., Koenig, M. D., Tussing-Humphreys, L., Chu, A., Lelić, M., Ganz, T., & Nemeth, E. (2019) · Journal of Clinical Investigation

Iron Metabolism and DisordersPregnancy and preeclampsia studies

Cited by 198

Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia

Rivera, S., Liu, L., Nemeth, E., Gabayan, V., Sorensen, O. E., & Ganz, T. (2005) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 196

Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells

Guo, W., Bachman, E., Li, M., Roy, C. N., Blusztajn, J., Wong, S., Chan, S. Y., Serra, C., Jasuja, R., Travison, T. G., et al. (2013) · Aging Cell

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 192

Urinary hepcidin in congenital chronic anemias

Kearney, S. L., Nemeth, E., Neufeld, E. J., Thapa, D., Ganz, T., Weinstein, D. A., & Cunningham, M. J. (2007) · Pediatric Blood & Cancer

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 172

The Hepcidin-Ferroportin System as a Therapeutic Target in Anemias and Iron Overload Disorders

Ganz, T., & Nemeth, E. (2011) · Hematology

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 172

Reduced serum hepcidin levels in patients with chronic hepatitis C

Girelli, D., Pasino, M., Goodnough, J. B., Nemeth, E., Guido, M., Castagna, A., Busti, F., Campostrini, N., Martinelli, N., Vantini, I., et al. (2009) · Journal of Hepatology

Iron Metabolism and DisordersHepatitis C virus research

Cited by 169

Erythroferrone contributes to recovery from anemia of inflammation

Kautz, L., Jung, G., Nemeth, E., & Ganz, T. (2014) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 152

Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera

Casu, C., Oikonomidou, P. R., Chen, H., Nandi, V., Ginzburg, Y., Prasad, P., Fleming, R. E., Shah, Y. M., Valore, E. V., Nemeth, E., et al. (2016) · Blood

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 148

Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron

Stefanova, D., Raychev, A., Arezes, J., Ruchala, P., Gabayan, V., Skurnik, M., Dillon, B. J., Horwitz, M. A., Ganz, T., Bulut, Y., et al. (2017) · Blood

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 145

A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin

Kim, A., Fung, E., Parikh, S. G., Valore, E. V., Gabayan, V., Nemeth, E., & Ganz, T. (2014) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 145

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

Ross, S. L., Tran, L., Winters, A., Lee, K.-J., Plewa, C., Foltz, I., King, C., Miranda, L. P., Allen, J., Beckman, H., et al. (2012) · Cell Metabolism

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 145