The Hepcidin-Ferroportin System as a Therapeutic Target in Anemias and Iron Overload Disorders
Open accessAbstract
The review summarizes the current understanding of the role of hepcidin and ferroportin in normal iron homeostasis and its disorders. The various approaches to therapeutic targeting of hepcidin and ferroportin in iron-overload disorders (mainly hereditary hemochromatosis and β-thalassemia) and iron-restrictive anemias (anemias associated with infections, inflammatory disorders, and certain malignancies, anemia of chronic kidney diseases, and iron-refractory iron-deficiency anemia) are also discussed.
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Inappropriate elevation of hepcidin levels yields iron-restricted anemia.
“By contrast, inappropriate elevation of hepcidin levels yields iron-restricted anemia 14,15 .”
From Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms (2020) · cites this paper as [15]
Different pharmaceutical preparations including antibodies, antichalins, Spiegelmers, thiamine derivatives, and heparin derivatives can bind and neutralize HAMP.
“Different pharmaceutical preparations including antibodies, antichalins, Spiegelmers, thiamine derivatives, and heparin derivatives can bind and neutralize HAMP [150, 151].”
From Iron deficiency or anemia of inflammation?: Differential diagnosis and mechanisms of anemia of inflammation (2016) · cites this paper as [151]
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- Authors
- Ganz, T., & Nemeth, E.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Hematology
- Publisher
- American Society of Hematology
- Published
- 2011-12-10
- Volume
- 2011
- Issue
- 1
- Pages
- 538-542
- ISSN
- 1520-4383 (ISSN-L)
- 1520-4391
- PMC
- PMC4034574
- OpenAlex
- W1980551377
- Cited by
- 172
- References
- 39
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 10 · 2021: 19 · 2020: 16 · 2019: 9 · 2018: 8 · 2017: 9 · 2016: 11 · 2015: 18 · 2014: 21 · 2013: 15 · 2012: 11
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hematology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK065029, R01DK082717)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Keywords
- hepcidin, ferroportin, iron homeostasis, iron overload, hereditary hemochromatosis, beta-thalassemia, anemia of chronic kidney disease, iron-refractory iron deficiency anemia, anemia of chronic disease, anemia of infection, anemia of malignancy, therapeutic targeting
- MeSH terms
- Ferroportin, Anemia, Humans, Iron Overload, Antimicrobial Cationic Peptides, Cation Transport Proteins, Molecular Targeted Therapy, Hepcidins
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